Clinical and neurocognitive aspects of hallucinations in Alzheimer's disease.
Clinical and neurocognitive aspects of hallucinations in Alzheimer's disease.
复制标题
阿尔茨海默氏病幻觉的临床和神经认知方面。
DOI：
10.1016/j.neubiorev.2017.02.021
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发表时间：
2017-12
影响因子：
8.2
通讯作者：
Antoine P
中科院分区：
文献类型：
--
作者：
El Haj M;Roche J;Jardri R;Kapogiannis D;Gallouj K;Antoine P
由于其普遍性，幻觉被认为是阿尔茨海默病（AD）最常见的精神病性症状之一。这些精神病性表现降低了患者的幸福感，增加了照顾者的负担，有助于早期机构化，并被发现与AD的认知下降过程有关。考虑到它们的后果，我们提供了一个全面的了解AD幻觉的患病率和特点的现状。我们提供了一个全面的和可测试的理论模型幻觉在AD：ALZHA（ALZheimer和HAllucinations）模型。在这个模型中，神经，遗传，认知，情感和医源性因素与AD幻觉突出。根据这个模型，AD中的幻觉首先涉及特质标记（即，认知缺陷、神经缺陷、遗传倾向和/或感觉缺陷），其中添加了可特异性触发这些经历的状态标记（例如，心理困扰和/或医源性因素）。最后，我们提供了评估和管理AD中这些精神病表现的建议，旨在为患者，护理人员和卫生专业人员提供服务。
Due to their prevalence, hallucinations are considered as one of the most frequent psychotic symptom in Alzheimer’s disease (AD). These psychotic manifestations reduce patients’ well-being, increase the burden of caregivers, contribute to early institutionalization, and are found to be related with the course of cognitive decline in AD. Considering their consequences, we provide a comprehensive account of the current state of knowledge about the prevalence and characteristics of hallucinations in AD. We provide a comprehensive and testable theoretical model about hallucinations in AD: the ALZHA (ALZheimer and HAllucinations) model. In this model, neurological, genetic, cognitive, affective, and iatrogenic factors associated with hallucinations in AD are highlighted. According to this model, hallucinations in AD first involve trait markers (i.e., cognitive deficits, neurological deficits, genetic predisposition and/or sensory deficits) to which state markers that may specifically trigger these experiences are added (e.g., psychological distress and/or iatrogenic factors). Finally, we provide recommendations for assessment and management of these psychotic manifestations in AD, with the aim to both serve patients, caregivers, and health professionals.
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