Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.
Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.
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DOI：
10.1371/journal.pone.0017608
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发表时间：
2011-03-08
期刊：
影响因子：
3.7
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Wang L;Wu XP;Zhang W;Zhu DH;Wang Y;Li YP;Tian Y;Li RC;Li Z;Zhu X;Li JH;Cai J;Liu L;Miao XP;Liu Y;Li H
最近的一项全基因组扫描发现，日本人HLA-DP区域的两种遗传变异与乙型肝炎感染密切相关。本研究评估了这些风险变异对中国人的影响，中国人是世界上HBV感染最流行的地方。我们在两个独立的病例对照研究中评估了这两个单核苷酸多态性（rs3077和rs9277535）与慢性乙型肝炎感染之间的关系。第一个人群是中国汉族，包括736例患者和782例自发康复的对照组。第二组在中国壮族177例患者和208例对照中建立。rs3077和rs9277535 A等位基因均显著降低中国汉族CHB发病风险（OR = 0.540, 95%CI: 0.464 ~ 0.628, P = 4.068×10−16;OR = 0.696, 95%CI: 0.601 ~ 0.806, P = 1.062×10−6）。可以想象，rs9277535与中国壮族人群患病风险降低相关，OR为0.606 （95%CI, 0.441-0.833, P = 0.002）。通过全基因组扫描在日本人群中鉴定出的HLA-DP区（rs3077和rs9277535）慢性乙型肝炎易感位点在中国人群中得到验证。这些发现可能为制定筛查和监测策略提供线索。
A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world. We have assessed the relationship between these two single nucleotide polymorphisms (rs3077 and rs9277535) and chronic hepatitis B infection in two independent case-control studies. The first population in Chinese Han included 736 patients and 782 spontaneously recovered controls. The second set was established in Chinese Zhuang minority of 177 patients and 208 controls. Both A alleles of rs3077 and rs9277535 significantly deceased the risk to CHB in Chinese Han (OR = 0.540, 95%CI: 0.464–0.628, P = 4.068×10−16 and OR = 0.696, 95%CI: 0.601–0.806, P = 1.062×10−6, respectively). Conceivably, rs9277535 was found to be associated with decreased risk of the disease in Chinese Zhuang, with an OR of 0.606 (95%CI, 0.441–0.833, P = 0.002). Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. These findings might provide clues to develop screening and surveillance strategies.
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DOI：
10.1038/nrg2760
发表时间：
2010-05
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1038/nrg2544
发表时间：
2009-05
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
Ioannidis JP;Thomas G;Daly MJ
通讯作者：
Daly MJ
影响因子：
13.5
作者：
Urbani, S;Boni, C;Ferrari, C
通讯作者：
Ferrari, C
影响因子：
56.9
作者：
Abdulla, Mahmood Ameen;Ahmed, Ikhlak;Zilfalil, Bin Alwi
通讯作者：
Zilfalil, Bin Alwi
影响因子：
2.7
作者：
Nicholson, I;Varney, M;Tait, BD
通讯作者：
Tait, BD