Vaccine Strategy That Enhances the Protective Efficacy of Systemic Immunization by Establishing Lung-Resident Memory CD8 T Cells Against Influenza Infection.
Vaccine Strategy That Enhances the Protective Efficacy of Systemic Immunization by Establishing Lung-Resident Memory CD8 T Cells Against Influenza Infection.
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DOI：
10.4110/in.2023.23.e32
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发表时间：
2023-08
期刊：
影响因子：
6
通讯作者：
Chang J
中科院分区：
文献类型：
--
作者：
Kong HJ;Choi Y;Kim EA;Chang J
目前使用的大多数流感疫苗靶向高度可变的血凝素蛋白以诱导中和抗体，因此需要每年重新配制。基于T细胞的通用流感疫苗集中于引发广泛的交叉反应性T细胞应答，特别是呼吸道中的组织驻留记忆T细胞（TRM）群体，从而为循环记忆T细胞提供上级保护。该研究表明，肌内（i.m.）施用表达流感病毒核蛋白的腺病毒疫苗（rAd/NP）在肺部和气道中引起较弱的CD 8 TRM反应，并且对致命流感病毒攻击的保护作用较差。然而，一种新颖的“预充和部署”策略，结合了i.m.接种rAd/NP并随后鼻内给予空腺病毒载体诱导了强NP特异性CD 8 + TRM细胞，并提供了针对流感病毒攻击的完全保护。总体而言，我们的研究结果表明，这种“预充和部署”的疫苗接种策略可能适用于通用流感疫苗的开发。
Most influenza vaccines currently in use target the highly variable hemagglutinin protein to induce neutralizing antibodies and therefore require yearly reformulation. T cell-based universal influenza vaccines focus on eliciting broadly cross-reactive T-cell responses, especially the tissue-resident memory T cell (TRM) population in the respiratory tract, providing superior protection to circulating memory T cells. This study demonstrated that intramuscular (i.m.) administration of the adenovirus-based vaccine expressing influenza virus nucleoprotein (rAd/NP) elicited weak CD8 TRM responses in the lungs and airways, and yielded poor protection against lethal influenza virus challenge. However, a novel “prime-and-deploy” strategy that combines i.m. vaccination of rAd/NP with subsequent intranasal administration of an empty adenovector induced strong NP-specific CD8+ TRM cells and provided complete protection against influenza virus challenge. Overall, our results demonstrate that this “prime-and-deploy” vaccination strategy is potentially applicable to the development of universal influenza vaccines.
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影响因子：
56.9
作者：
Mao, Tianyang;Israelow, Benjamin;Pena-Hernandez, Mario A.;Suberi, Alexandra;Zhou, Liqun;Luyten, Sophia;Reschke, Melanie;Dong, Huiping;Homer, Robert J.;Saltzman, W. Mark;Iwasaki, Akiko
通讯作者：
Iwasaki, Akiko
影响因子：
8
作者：
Caminschi, Irina;Lahoud, Mireille H.;Wakim, Linda M.
通讯作者：
Wakim, Linda M.
影响因子：
56.9
作者：
Altman, JD;Moss, PAH;Davis, MM
通讯作者：
Davis, MM
DOI：
10.1038/s41572-018-0002-y
发表时间：
2018-06-28
期刊：
Nature reviews. Disease primers
影响因子：
--
作者：
Krammer F;Smith GJD;Fouchier RAM;Peiris M;Kedzierska K;Doherty PC;Palese P;Shaw ML;Treanor J;Webster RG;García-Sastre A
通讯作者：
García-Sastre A
影响因子：
13.6
作者：
Bull MB;Gu H;Ma FNL;Perera LP;Poon LLM;Valkenburg SA
通讯作者：
Valkenburg SA