Probabilistic finite element analysis of radiofrequency liver ablation using the unscented transform.

Probabilistic finite element analysis of radiofrequency liver ablation using the unscented transform.
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DOI:
10.1088/0031-9155/54/3/010
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发表时间:
2009-02-07
影响因子:
3.5
通讯作者:
Menezes LR
Menezes LR
中科院分区:
工程技术2区
文献类型:
--
作者:
Dos Santos I;Haemmerich D;Schutt D;da Rocha AF;Menezes LR

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文献中报告的射频(RF)消融数值模拟的主要局限性是它们未能提供基于组织热电参数统计变异性的统计结果。这项工作开发了一种有效的概率方法,肝脏射频消融,以统计学评估的影响,四个热-电性能的肝脏组织的消融区尺寸的不确定性:导热系数,比热,血液灌注和电导率。一个确定性的热-电有限元模型的单极电极插入在肝脏中耦合的无迹变换方法,以获得凝固区的置信区间,概率和累积密度函数。凝固区体积、直径和长度分别为10.96cm ~ 3、2.17cm和4.08cm(P < 0.01)。此外,概率敏感性分析表明,灌注和导热性占凝固区体积、直径和长度变异性的>95%。
The main limitation of radiofrequency (RF) ablation numerical simulations reported in the literature is their failure to provide statistical results based on the statistical variability of tissue thermal–electrical parameters. This work developed an efficient probabilistic approach to hepatic RF ablation in order to statistically evaluate the effect of four thermal–electrical properties of liver tissue on the uncertainty of the ablation zone dimensions: thermal conductivity, specific heat, blood perfusion and electrical conductivity. A deterministic thermal–electrical finite element model of a monopolar electrode inserted in the liver was coupled with the unscented transform method in order to obtain coagulation zone confidence intervals, probability and cumulative density functions. The coagulation zone volume, diameter and length were 10.96 cm3, 2.17 cm and 4.08 cm, respectively (P < 0.01). Furthermore, a probabilistic sensitivity analysis showed that perfusion and thermal conductivity account for >95% of the variability in coagulation zone volume, diameter and length.
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