An influenza A (H3N2) virus outbreak in the Kingdom of Cambodia during the COVID-19 pandemic of 2020.
An influenza A (H3N2) virus outbreak in the Kingdom of Cambodia during the COVID-19 pandemic of 2020.
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DOI：
10.1016/j.ijid.2020.11.178
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发表时间：
2021-02
影响因子：
8.4
通讯作者：
Mott, J. A.
中科院分区：
文献类型：
--
作者：
Sovann, L. Y.;Sar, B.;Kab, V;Yann, S.;Kinzer, M.;Raftery, P.;Albalak, R.;Patel, S.;Hay, P. Long;Seng, H.;Um, S.;Chin, S.;Chau, D.;Khalakdina, A.;Karlsson, E.;Olsen, S. J.;Mott, J. A.
新冠肺炎大流行期间，全球流感病毒传播减少，可能是由于社区广泛采取缓解措施所致。柬埔寨在2020年6月和7月放松了一些新冠肺炎的缓解措施。8月20日，在一座宝塔的居民中发生了一系列呼吸道疾病，其中包括甲型流感检测呈阳性但没有人对SARS-CoV-2呈阳性。2020年8月25日部署了一个反应小组。流感样疾病(ILI)患者被问及有关人口统计学、疾病、个人预防措施和居住安排的问题。用实时荧光定量逆转录聚合酶链式反应检测呼吸道拭子中的流感病毒和SARS-CoV-2，并对病毒进行测序。对哨兵监测数据进行了分析，以评估社区流感传播的最新趋势。在报告的宝塔暴发之前，于2020年7月在柬埔寨的哨兵监测期间发现了甲型H3N2流感病毒。在362名宝塔居民中，73例(20.2%)确诊为ILI病例，40例进行了检测，其中33/40例(82.5%)甲型H3N1流感确诊。40人均为SARS-CoV-2阴性。在73名ILI患者中，没有接种过流感疫苗，47人(%)聚集在3/8个睡眠区，20人(27%)报告经常戴口罩，27人(36%)报告经常洗手，11人(15%)报告实践社交距离。所有病毒都聚集在3c2.a1分支内，与2020年在澳大利亚流行的毒株接近。随着国家新冠肺炎缓解措施的放松，流感病毒在社区开始传播，在疫情爆发之前，在一个与社会距离有限的宝塔里。需要继续监测和接种流感疫苗，以限制全球流感的影响。
Global influenza virus circulation decreased during the COVID-19 pandemic, possibly due to widespread community mitigation measures. Cambodia eased some COVID-19 mitigation measures in June and July 2020. On 20 August a cluster of respiratory illnesses occurred among residents of a pagoda, including people who tested positive for influenza A but none who were positive for SARS-CoV-2. A response team was deployed on 25 August 2020. People with influenza-like illness (ILI) were asked questions regarding demographics, illness, personal prevention measures, and residential arrangements. Respiratory swabs were tested for influenza and SARS-Cov-2 by real-time reverse transcription PCR, and viruses were sequenced. Sentinel surveillance data were analyzed to assess recent trends in influenza circulation in the community. Influenza A (H3N2) viruses were identified during sentinel surveillance in Cambodia in July 2020 prior to the reported pagoda outbreak. Among the 362 pagoda residents, 73 (20.2%) ILI cases were identified and 40 were tested, where 33/40 (82.5%) confirmed positive for influenza A (H3N2). All 40 were negative for SARS-CoV-2. Among the 73 residents with ILI, none were vaccinated against influenza, 47 (64%) clustered in 3/8 sleeping quarters, 20 (27%) reported often wearing a mask, 27 (36%) reported often washing hands, and 11 (15%) reported practicing social distancing. All viruses clustered within clade 3c2.A1 close to strains circulating in Australia in 2020. Circulation of influenza viruses began in the community following the relaxation of national COVID-19 mitigation measures, and prior to the outbreak in a pagoda with limited social distancing. Continued surveillance and influenza vaccination are required to limit the impact of influenza globally.
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