SARS-CoV-2 placentitis, stillbirth, and maternal COVID-19 vaccination: clinical-pathologic correlations.
SARS-CoV-2 placentitis, stillbirth, and maternal COVID-19 vaccination: clinical-pathologic correlations.
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DOI：
10.1016/j.ajog.2022.10.001
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发表时间：
2023-03
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
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作者：
死产是孕妇中公认的 COVID-19 并发症，最近被证明是由胎盘 SARS-CoV-2 感染引起的。多项全球研究发现，死产病例中存在的胎盘病理由同时发生的破坏性结果组合而成，包括纤维蛋白沉积增加，通常达到大量绒毛周围纤维蛋白沉积的水平、慢性组织细胞绒毛间炎和滋养层坏死。这 3 种病理病变统称为 SARS-CoV-2 胎盘炎，可引起严重、弥漫性胎盘实质破坏，可影响 > 75% 的胎盘，使其无法履行为胎儿供氧的功能，并因灌注不良和胎盘功能不全而导致死产和新生儿死亡。在没有明显的胎儿感染的情况下，可能会发生胎盘感染和破坏。 SARS-CoV-2 胎盘炎的发展是一个复杂的过程，可能具有感染性和免疫学基础。一个重要的观察结果是，在所有报告的导致死产和新生儿死亡的 SARS-CoV-2 胎盘炎病例中，母亲均未接种疫苗。 SARS-CoV-2 胎盘炎可能是妊娠期间某个时间出现 SARS-CoV-2 病毒血症的结果。本文讨论了孕产妇 COVID-19 疫苗接种、SARS-CoV-2 胎盘炎和围产期死亡之间关系的临床和病理学方面。
Stillbirth is a recognized complication of COVID-19 in pregnant women that has recently been demonstrated to be caused by SARS-CoV-2 infection of the placenta. Multiple global studies have found that the placental pathology present in cases of stillbirth consists of a combination of concurrent destructive findings that include increased fibrin deposition that typically reaches the level of massive perivillous fibrin deposition, chronic histiocytic intervillositis, and trophoblast necrosis. These 3 pathologic lesions, collectively termed SARS-CoV-2 placentitis, can cause severe and diffuse placental parenchymal destruction that can affect >75% of the placenta, effectively rendering it incapable of performing its function of oxygenating the fetus and leading to stillbirth and neonatal death via malperfusion and placental insufficiency. Placental infection and destruction can occur in the absence of demonstrable fetal infection. Development of SARS-CoV-2 placentitis is a complex process that may have both an infectious and immunologic basis. An important observation is that in all reported cases of SARS-CoV-2 placentitis causing stillbirth and neonatal death, the mothers were unvaccinated. SARS-CoV-2 placentitis is likely the result of an episode of SARS-CoV-2 viremia at some time during the pregnancy. This article discusses clinical and pathologic aspects of the relationship between maternal COVID-19 vaccination, SARS-CoV-2 placentitis, and perinatal death.
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影响因子：
9.8
作者：
Gurol-Urganci I;Jardine JE;Carroll F;Draycott T;Dunn G;Fremeaux A;Harris T;Hawdon J;Morris E;Muller P;Waite L;Webster K;van der Meulen J;Khalil A
通讯作者：
Khalil A
DOI：
10.1016/j.diagmicrobio.2021.115595
发表时间：
2022-03
影响因子：
2.9
作者：
Hagman K;Hedenstierna M;Rudling J;Gille-Johnson P;Hammas B;Grabbe M;Jakobsson J;Dillner J;Ursing J
通讯作者：
Ursing J
影响因子：
7.3
作者：
Goldstein JA;Gallagher K;Beck C;Kumar R;Gernand AD
通讯作者：
Gernand AD
DOI：
10.15585/mmwr.mm7107e3
发表时间：
2022-02-18
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Halasa NB;Olson SM;Staat MA;Newhams MM;Price AM;Boom JA;Sahni LC;Cameron MA;Pannaraj PS;Bline KE;Bhumbra SS;Bradford TT;Chiotos K;Coates BM;Cullimore ML;Cvijanovich NZ;Flori HR;Gertz SJ;Heidemann SM;Hobbs CV;Hume JR;Irby K;Kamidani S;Kong M;Levy ER;Mack EH;Maddux AB;Michelson KN;Nofziger RA;Schuster JE;Schwartz SP;Smallcomb L;Tarquinio KM;Walker TC;Zinter MS;Gilboa SM;Polen KN;Campbell AP;Randolph AG;Patel MM;Overcoming COVID-19 Investigators;Overcoming COVID-19 Network
通讯作者：
Overcoming COVID-19 Network
影响因子：
9.8
作者：
Benachi, Alexandra;Rabant, Marion;Zuber, Julien
通讯作者：
Zuber, Julien