PET/MRI in head and neck cancer: initial experience.
PET/MRI in head and neck cancer: initial experience.
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DOI：
10.1007/s00259-012-2248-z
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发表时间：
2013-01
影响因子：
9.1
通讯作者：
van den Hoff, Joerg
中科院分区：
文献类型：
--
作者：
Platzek, Ivan;Beuthien-Baumann, Bettina;Schneider, Matthias;Gudziol, Volker;Langner, Jens;Schramm, Georg;Laniado, Michael;Kotzerke, Joerg;van den Hoff, Joerg
目的评价PET/MRI（正电子发射断层扫描/磁共振成像）结合FDG（18 F-氟脱氧葡萄糖）对头颈部肿瘤进行初步分期的可行性。研究组包括20名患者（16名男性，4名女性），年龄在52至81岁之间（中位数64岁），组织学证实为头颈部鳞状细胞癌。患者在常规扫描仪上进行PET扫描，随后在全身混合系统上进行PET/MRI检查。常规PET扫描前静脉注射FDG（267-395 MBq FDG，平均348 MBq）。确定两个PET数据集的肿瘤和两个小脑半球的最大标准化摄取值（SUVmax）。比较两个PET数据集之间FDG摄取增加的淋巴结数量。在PET图像中未观察到MRI诱导的伪影。20名患者中有17名通过PET/MRI检测到肿瘤，16名通过PET检测到肿瘤，14名通过MRI检测到肿瘤。对于肿瘤（p < 0.0001）和小脑（p = 0.0009），PET/MRI检查产生的SUVmax显著高于传统PET扫描仪。使用PET/MRI系统的PET数据集检测到的FDG摄取增加的淋巴结数量显著高于独立PET系统检测到的数量（64 vs. 39，p = 0.001）。当前研究表明，使用全身PET/MRI系统对整个头颈部区域进行PET/MRI是可行的，不会损害PET或MR图像质量。
To evaluate the feasibility of PET/MRI (positron emission tomography/magnetic resonance imaging) with FDG (18F-fluorodeoxyglucose) for initial staging of head and neck cancer. The study group comprised 20 patients (16 men, 4 women) aged between 52 and 81 years (median 64 years) with histologically proven squamous cell carcinoma of the head and neck region. The patients underwent a PET scan on a conventional scanner and a subsequent PET/MRI examination on a whole-body hybrid system. FDG was administered intravenously prior to the conventional PET scan (267–395 MBq FDG, 348 MBq on average). The maximum standardized uptake values (SUVmax) of the tumour and of both cerebellar hemispheres were determined for both PET datasets. The numbers of lymph nodes with increased FDG uptake were compared between the two PET datasets. No MRI-induced artefacts where observed in the PET images. The tumour was detected by PET/MRI in 17 of the 20 patients, by PET in 16 and by MRI in 14. The PET/MRI examination yielded significantly higher SUVmax than the conventional PET scanner for both the tumour (p < 0.0001) and the cerebellum (p = 0.0009). The number of lymph nodes with increased FDG uptake detected using the PET dataset from the PET/MRI system was significantly higher the number detected by the stand-alone PET system (64 vs. 39, p = 0.001). The current study demonstrated that PET/MRI of the whole head and neck region is feasible with a whole-body PET/MRI system without impairment of PET or MR image quality.
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影响因子：
3.5
作者：
Zaidi H;Ojha N;Morich M;Griesmer J;Hu Z;Maniawski P;Ratib O;Izquierdo-Garcia D;Fayad ZA;Shao L
通讯作者：
Shao L
DOI：
10.1007/s10334-012-0328-5
发表时间：
2013-02
影响因子：
2.3
作者：
Schramm, Georg;Langner, Jens;Hofheinz, Frank;Petr, Jan;Beuthien-Baumann, Bettina;Platzek, Ivan;Steinbach, Joerg;Kotzerke, Joerg;van den Hoff, Joerg
通讯作者：
van den Hoff, Joerg
影响因子：
1.6
作者：
Fuchtner, F;Steinbach, J;Johannsen, B
通讯作者：
Johannsen, B
DOI：
10.3390/s101110484
发表时间：
2010
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Spanoudaki VCh;Levin CS
通讯作者：
Levin CS
影响因子：
19.7
作者：
King, AD;Tse, GMK;van Hasselt, AC
通讯作者：
van Hasselt, AC