Insomnia symptoms, objective sleep duration and hypothalamic-pituitary-adrenal activity in children.
Insomnia symptoms, objective sleep duration and hypothalamic-pituitary-adrenal activity in children.
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儿童失眠症状，客观睡眠持续时间和下丘脑 - 垂体 - 肾上腺活性。
DOI：
10.1111/eci.12263
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发表时间：
2014-05
影响因子：
5.5
通讯作者：
Bixler EO
中科院分区：
文献类型：
--
作者：
Fernandez-Mendoza J;Vgontzas AN;Calhoun SL;Vgontzas A;Tsaoussoglou M;Gaines J;Liao D;Chrousos GP;Bixler EO
Insomnia symptoms are the most common parent-reported sleep complaints in children; however, little is known about the pathophysiology of childhood insomnia symptoms, including their association with hypothalamic-pituitary-adrenal (HPA) axis activation. The objective of this study is to examine the association between parent-reported insomnia symptoms, objective short sleep duration and cortisol levels in a population-based sample of school-aged children. A sample of 327 children from the Penn State Child Cohort (5–12 years old) underwent 9-h overnight polysomnography and provided evening and morning saliva samples to assay for cortisol. Objective short sleep duration was defined based on the median total sleep time (i.e., < 7·7 h). Parent-reported insomnia symptoms of difficulty initiating and/or maintaining sleep were ascertained with the Pediatric Behavior Scale. Children with parent-reported insomnia symptoms and objective short sleep duration showed significantly increased evening (0·33 ± 0·03 μg/dL) and morning (1·38 ± 0·08 μg/dL) cortisol levels. In contrast, children with parent-reported insomnia symptoms and ‘normal’ sleep duration showed similar evening and morning cortisol levels (0·23 ± 0·03 μg/dL and 1·13 ± 0·08 μg/dL) compared with controls with ‘normal’ (0·28 ± 0·02 μg/dL and 1·10 ± 0·04 μg/dL) or short (0·28 ± 0·02 μg/dL and 1·13 ± 0·04 μg/dL) sleep duration. Our findings suggest that insomnia symptoms with short sleep duration in children may be related to 24-h basal or responsive physiological hyperarousal. Future studies should explore the association of insomnia symptoms with short sleep duration with physical and mental health morbidity.
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影响因子：
4.8
作者：
Calhoun, Susan L.;Fernandez-Mendoza, Julio;Vgontzas, Alexandros N.;Liao, Duanping;Bixler, Edward O.
通讯作者：
Bixler, Edward O.
影响因子：
5.6
作者：
BONNET, MH;ARAND, DL
通讯作者：
ARAND, DL
影响因子：
3.3
作者：
Bonnet, MH;Arand, DL
通讯作者：
Arand, DL
影响因子：
4.1
作者：
LICHSTEIN, KL;JOHNSON, RS;DYKSTRA, TA
通讯作者：
DYKSTRA, TA
影响因子：
4.6
作者：
FREEDMAN, RR;SATTLER, HL
通讯作者：
SATTLER, HL