Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis.
Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis.
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具有自我再生水合层的可注射水凝胶微球可缓解骨关节炎。
DOI：
10.1126/sciadv.abl6449
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发表时间：
2022-02-04
期刊：
影响因子：
13.6
通讯作者：
Huang W
中科院分区：
文献类型：
--
作者：
Lei Y;Wang Y;Shen J;Cai Z;Zhao C;Chen H;Luo X;Hu N;Cui W;Huang W
Introducing hydration layers to hydrogel microspheres (HMs) by coating the surface with liposomes can effectively reduce friction. However, the lubrication can be inactivated when the surface coatings are damaged. To endow HMs with the ability to form self-renewable hydration layers and maintain cellular homeostasis, rapamycin-liposome–incorporating hyaluronic acid–based HMs (RAPA@Lipo@HMs) were created using microfluidic technology and photopolymerization processes. The RAPA@Lipo@HMs improve joint lubrication by using a smooth rolling mechanism and continuously exposing liposomes on the outer surface to form self-renewable hydration layers via frictional wear. In addition, the released autophagy activator (rapamycin)–loaded cationic liposomes can target negatively charged cartilage through electrostatic interactions and maintain cellular homeostasis by increasing autophagy. Furthermore, the in vivo data showed that the RAPA@Lipo@HMs can alleviate joint wear and delay the progression of osteoarthritis. The RAPA@Lipo@HMs can provide efficient lubrication and potentially alleviate friction-related diseases such as osteoarthritis. Self-lubricating drug-loaded hydrogel microspheres provide stable lubrication and maintain cellular homeostasis.
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影响因子：
5.6
作者：
Hu Q;Ecker M
通讯作者：
Ecker M
影响因子：
33.7
作者：
Bajpayee, Ambika G.;Grodzinsky, Alan J.
通讯作者：
Grodzinsky, Alan J.
软骨基质启发的仿生超润滑纳米球用于治疗骨关节炎
影响因子：
14
作者：
Chen, Hao;Sun, Tao;Zhang, Hongyu
通讯作者：
Zhang, Hongyu
DOI：
10.1002/advs.202004793
发表时间：
2021-05
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Chen Z;Zhang F;Zhang H;Cheng L;Chen K;Shen J;Qi J;Deng L;He C;Santos HA;Cui W
通讯作者：
Cui W
影响因子：
13.3
作者：
Liu W;Xu L;Wang X;Zhang D;Sun G;Wang M;Wang M;Han Y;Chai R;Wang H
通讯作者：
Wang H