Probing thalamic integrity in schizophrenia using concurrent transcranial magnetic stimulation and functional magnetic resonance imaging.
Probing thalamic integrity in schizophrenia using concurrent transcranial magnetic stimulation and functional magnetic resonance imaging.
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DOI：
10.1001/archgenpsychiatry.2012.23
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发表时间：
2012-07
影响因子：
--
通讯作者：
Postle, Bradley R.
中科院分区：
文献类型：
--
作者：
Guller, Yelena;Ferrarelli, Fabio;Shackman, Alexander J.;Sarasso, Simone;Peterson, Michael J.;Langheim, Frederick J.;Meyerand, Mary E.;Tononi, Giulio;Postle, Bradley R.
精神分裂症是一种致命性疾病，其病理生理机制尚不明确。有几条证据表明丘脑功能障碍，丘脑是感知、情感和认知基础的分布式神经网络的关键节点。丘脑功能异常的现有证据是基于丘脑活动的间接测量，但功能障碍尚未通过因果方法得到证实。测试这样一种假设，即对大脑皮层的直接生理刺激会在精神分裂症患者中产生异常的丘脑反应。我们用单脉冲经颅磁刺激(SpTMS)刺激中央前回，并用同步功能磁共振成像(FMRI)测量突触连接区域(丘脑、额叶内侧上皮质[MSFG]、脑岛)对该脉冲的反应。这些区域的平均血流动力学反应用两个伽玛函数之和来拟合，并比较不同组间的反应参数。学术研究实验室。精神分裂症患者和性别和年龄匹配的精神健康受试者从社区招募。丘脑血流动力学对中央前回SPTMS反应的峰值。在皮质刺激部位，SPTMS诱发的反应在不同组之间没有差异。与健康人相比，精神分裂症患者丘脑(P=1.86×10-−9)和MSFG(P=0.02)对SPTMS的反应降低。在岛上也观察到了类似的结果。SHAM TMS表明，这些结果不能归因于TMS线圈放电的间接影响。功能连接性分析显示，与对照组相比，精神分裂症患者丘脑-MSFG和丘脑-岛的连接性较弱。精神分裂症患者表现出丘脑对传递到大脑皮层的直接干扰的反应减少。这些结果扩展了之前的工作，即丘脑参与了精神分裂症的病理生理学，并表明丘脑参与了这种疾病的异常连接特征的模式。
Schizophrenia is a devastating illness with an indeterminate pathophysiology. Several lines of evidence implicate dysfunction in the thalamus, a key node in the distributed neural networks underlying perception, emotion, and cognition. Existing evidence of aberrant thalamic function is based on indirect measures of thalamic activity, but dysfunction has not yet been demonstrated with a causal method. Test the hypothesis that direct physiological stimulation of cortex will produce an abnormal thalamic response in individuals with schizophrenia. We stimulated the precentral gyrus with single-pulse transcranial magnetic stimulation (spTMS) and measured the response to this pulse in synaptically-connected regions (thalamus, medial superior frontal cortex [mSFG], insula) using concurrent functional magnetic resonance imaging (fMRI). The mean hemodynamic response from these regions was fit with the sum of two gamma functions and response parameters were compared across groups. Academic research laboratory. Patients with schizophrenia and sex- and age- matched psychiatrically healthy subjects were recruited from the community. Peak amplitude of the thalamic hemodynamic response to spTMS of precentral gyrus. spTMS-evoked responses did not differ between groups at the cortical stimulation site. Compared to healthy subjects, schizophrenia patients showed a reduced response to spTMS in the thalamus (P=1.86 × 10−9) and mSFG (P=.02). Similar results were observed in the insula. Sham TMS indicated that these results could not be attributed to indirect effects of TMS coil discharge. Functional connectivity analyses revealed weaker thalamus-mSFG and thalamus-insula connectivity in schizophrenia patients compared to control subjects. Individuals with schizophrenia showed reduced thalamic activation in response to direct perturbation delivered to the cortex. These results extend prior work implicating the thalamus in the pathophysiology of schizophrenia and suggest that the thalamus contributes to the patterns of aberrant connectivity characteristic of this disease.
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影响因子：
10.6
作者：
Carter, Cameron S.;Barch, Deanna M.;Bullmore, Edward T.;Breiling, James;Buchanan, Robert W.;Butler, Pamela;Cohen, Jonathan D.;Geyer, Mark;Gollub, Randy;Green, Michael F.;Jaeger, Judith;Krystal, John H.;Moore, Holly;Nuechterlein, Keith;Robbins, Trevor;Silverstein, Steven;Smith, Edward E.;Strauss, Milton;Wykes, Til
通讯作者：
Wykes, Til
影响因子：
6.6
作者：
Ferrarelli, Fabio;Tononi, Giulio
通讯作者：
Tononi, Giulio
影响因子：
4.8
作者：
Corradi-Dell'Acqua, Corrado;Tomelleri, Luisa;Brambilla, Paolo
通讯作者：
Brambilla, Paolo
影响因子：
1.9
作者：
Corring, DJ
通讯作者：
Corring, DJ
顶壁TMS对体感觉反应的半球间影响直接与并发的TMS-FMRI证实。
DOI：
10.1523/jneurosci.3043-08.2008
发表时间：
2008-12-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Blankenburg F;Ruff CC;Bestmann S;Bjoertomt O;Eshel N;Josephs O;Weiskopf N;Driver J
通讯作者：
Driver J