Longitudinal evaluation of GCF IFN-gamma levels and periodontal status in HIV+ patients.
Longitudinal evaluation of GCF IFN-gamma levels and periodontal status in HIV+ patients.
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HIV 患者 GCF IFN-γ 水平和牙周状态的纵向评估。
DOI：
10.1034/j.1600-051x.2003.00403.x
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发表时间：
2003
影响因子：
6.7
通讯作者：
Lee,A
中科院分区：
文献类型：
--
作者：
Alpagot,T;Font,K;Lee,A
摘要背景/目的：在HIV阳性患者中，牙周支持丧失和相关牙齿脱落是一种常见的发现。这种破坏的原因可能是促炎细胞因子水平的增加和随后牙周病活动的增加。本研究的目的是探讨人类免疫缺陷病毒感染者牙周病临床指标与牙周液干扰素-γ之间的关系。方法：对33例HIV阳性受试者进行为期6个月的牙周状况监测，包括牙龈指数、菌斑指数、探诊出血量、探诊深度、附着丧失(AL)和牙周液标本，分别于基线和6个月时用无菌纸条采集患者下切牙和右上后六分体的牙周组织标本。用双抗体夹心ELISA法测定牙周液中干扰素-γ的水平。进展点定义为在6个月的研究期间有2 mm或以上AL的部位。结果：在6个月的研究期间，2 64个检查点中有2 5个有2 mm或以上的临床AL。进展部位的干扰素-γ水平显著高于非进展部位(p<；0.001)。干扰素-γ的牙周液水平与基线和6个月的临床测量结果高度相关(0.001；t；p<；0.01)。结论：这些数据表明，在HIV阳性患者中，牙周液中干扰素-γ的水平越高，牙周炎进展的风险越大。
AbstractBackground/Aim:Loss of periodontal support and related tooth loss is a common finding among HIV+patients. The etiology of this destruction may be an increase in the levels of pro‐inflammatory cytokines and subsequent increase in periodontal disease activity. The purpose of this study was to investigate the associations between gingival crevicular fluid interferon gamma (GCF IFN‐γ) and clinical measures of periodontal disease in HIV+individuals. We monitored GCF IFN‐γand periodontal status of selected sites in 33 HIV+subjects over a 6‐month period.Method:Clinical measurements including gingival index, plaque index, bleeding on probing, probing depth, attachment loss (AL), and GCF samples were taken from four lower incisors and the upper right posterior sextant of each patient at baseline and 6‐month visits by means of sterile paper strips. GCF levels of IFN‐γwere determined by sandwich ELISA assays. A progressing site was defined as a site that had 2 mm or more AL during the 6‐month study period.Results:Twenty‐five of the 264 examination sites showed 2 mm or more clinical AL during the 6‐month study period. Significantly higher GCF levels of IFN‐γwere found at progressing sites than in nonprogressing sites (p<0.001). GCF levels of IFN‐γwere highly correlated with clinical measurements taken at baseline and 6‐month visits (0.001<p<0.01).Conclusion:These data indicate that sites with high GCF levels of IFN‐γare at significantly greater risk for progression of periodontitis in HIV+patients.
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影响因子：
4.3
作者：
YEUNG, SCH;STEWART, GJ;SINDHUSAKE, D
通讯作者：
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DOI：
--
发表时间：
1990
期刊：
影响因子：
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作者：
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作者：
LISTGARTEN, MA
通讯作者：
LISTGARTEN, MA
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
LOE, HARALD;SILNESS, JOHN
通讯作者：
SILNESS, JOHN