Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?
Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?
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DOI：
10.1016/j.bjorl.2019.08.006
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发表时间：
2020-01
影响因子：
2.2
通讯作者：
Hwang, Se Hwan
中科院分区：
文献类型：
--
作者：
Kang, Haram;Hwang, Se Hwan
氨甲环酸是一种止血剂，可以抑制纤维蛋白的降解，这可能有助于控制术中出血。本研究的目的是对氨甲环酸在鼻内窥镜手术中对出血和手术野的影响以及对患者的副作用进行荟萃分析和综述。从文章收集开始到2018年7月，两位作者独立搜索了6个数据库(Medline、Scopus、Embase、Web of Science、Google Scholar和Cochrane图书馆)。术中出血、手术时间、低血压、恶心、呕吐和凝血谱等术后并发症纳入术中氨甲环酸(治疗组)和安慰剂(对照组)的分析。与安慰剂组相比，治疗组术中失血量在统计学上更低，而手术场质量在统计学上高于安慰剂组。另一方面，两组之间在手术时间、血流动力学或凝血情况方面没有显著差异。此外，与对照组相比，氨甲环酸对呕吐和血栓形成没有显著影响。这项荟萃分析表明，局部应用氨甲环酸可以减少手术中的出血量，提高手术的整体质量。术中血流动力学不稳定、术后呕吐或凝血谱异常均未见报道。需要更多的研究来证实这项研究的结果，因为研究较少。
Tranexamic acid is a hemostatic agent, which inhibits fibrin degradation, which may be beneficial in controlling bleeding during surgery. The purpose of this study was to provide a meta-analysis and review of the effects of tranexamic acid on hemorrhage and surgical fields and side effects on patients during endoscopic sinus surgery. Two authors independently searched six databases (Medline, Scopus, Embase, Web of Science, Google Scholar and Cochrane library) from the start of article collection until July 2018. Postoperative complications such as intraoperative bleeding, operative time, hypotension, nausea, vomiting, and coagulation profile were included in the analysis of tranexamic acid (Treatment Group) and placebo (Control Group) during the operation. The amount of blood loss during surgery was statistically lower in the treatment group compared to the placebo group, and the surgical field quality was statistically higher in the treatment group than in the placebo group. On the other hand, there was no significant difference in operation time, hemodynamics, or coagulation profile between groups. In addition, tranexamic acid had no significant effect on vomiting and thrombosis compared to the Control Group. This meta-analysis has shown that topical administration of tranexamic acid can reduce the amount of bleeding during surgery and improve the overall quality of the surgery. Hemodynamic instability during surgery, vomiting after surgery, or abnormal clotting profile were not reported. Additional studies are needed to confirm the results of this study because there are fewer studies.
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术中右美托咪定输注对内窥镜鼻窦手术中手术场的可视化功效。
影响因子：
2.9
作者：
Kim H;Ha SH;Kim CH;Lee SH;Choi SH
通讯作者：
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影响因子：
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作者：
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Poorolajal, Jalal
DOI：
10.2500/ajr.2007.21.3097
发表时间：
2007-11-01
期刊：
AMERICAN JOURNAL OF RHINOLOGY
影响因子：
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作者：
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通讯作者：
Wormald, Peter J.
影响因子：
0.4
作者：
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通讯作者：
Abd-El-Fattah, Mohammed Hamed
DOI：
10.1111/j.1749-6632.1964.tb50692.x
发表时间：
1964-01-01
影响因子：
5.2
作者：
BUNKER, JP
通讯作者：
BUNKER, JP