The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance
The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance
复制标题
糖耐量正常老年人血浆DPP4活性与BDNF比值与轻度认知障碍的关系
DOI：
10.3389/fnagi.2019.00033
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发表时间：
2019-03
影响因子：
4.8
通讯作者：
Zheng Tianpeng
中科院分区：
文献类型：
--
作者：
Xiao Liuping;Ge Bo;Chen Xu;Chen Bo;Qin Linyuan;Hu Xueping;Pan Haidong;Chen Yujie;Tian Li;Gao Yun;Zheng Tianpeng
目的：由于脑源性神经营养因子（BDNF）的降低和二肽基肽酶-4 （DPP4）活性的升高都与轻度认知障碍（MCI）的发病机制有关，本研究的目的是评估在糖耐量正常的老年人群中，MCI与血浆DPP4活性与BDNF比值（DBR）的关系。方法：我们横断面测量了中国1066名老年人的c反应蛋白、白介素-6、硝基酪氨酸、8-iso-PGF2a、DPP4活性BDNF，并计算了DBR。MCI由蒙特利尔认知评估确定，最终由神经科医生确认。结果：DPP4活性与BDNF呈负相关（r = -0.456, P < 0.001），这种负相关部分是由硝基酪氨酸和8-iso-PGF2a介导的。在DBR上升的四分位数中，硝基酪氨酸、8-iso-PGF2a、c反应蛋白和白细胞介素-6逐渐增加，而蒙特利尔认知评估评分逐渐下降。BDNF最低四分位数、DBR和DPP4活性最高四分位数的受试者患MCI的风险分别高于BDNF最高四分位数、DBR和DPP4活性最低四分位数的受试者（均P < 0.05）。随着BDNF的减少和DPP4的增加，MCI的优势比变得更加明显。结论：DPP4活性与BDNF呈负相关，这种负相关部分是由氧化应激介导的，而非炎症。DBR与MCI呈正相关，因此可以作为葡萄糖耐量正常的老年人群MCI的一种新的风险生物标志物。
Objective: Since decreased brain-derived neurotrophic factor (BDNF) and increased dipeptidyl peptidase-4 (DPP4) activity have both been implicated in the pathogenesis of mild cognitive impairment (MCI), the aim of our study was to evaluate the association of MCI with plasma DPP4 activity to BDNF ratio (DBR) in an elderly population with normal glucose tolerance. Methods: We cross-sectionally measured C-reactive protein, interleukin-6, nitrotyrosine, 8-iso-PGF2a, DPP4 activity BDNF and calculated the DBR in a total of 1,066 elderly participants in China. MCI was determined by the Montreal Cognitive Assessment and finally confirmed by neurologists. Results: An inverse correlation was found between DPP4 activity and BDNF (r = -0.456, P < 0.001) and this inverse correlation was partly mediated by nitrotyrosine and 8-iso-PGF2a. Across rising quartiles of DBR, nitrotyrosine, 8-iso-PGF2a, C-reactive protein and interleukin-6 progressively increased, whereas the Montreal Cognitive Assessment score progressively decreased. Subjects in the lowest quartile of BDNF and highest quartiles of DBR and DPP4 activity, had higher MCI risk compared with subjects in the highest quartile of the BDNF and lowest quartiles of DBR and DPP4 activity, respectively (all P < 0.05). The odds ratio for MCI became more pronounced with decreased BDNF and increased DPP4. Conclusion: In conclusion, a negative correlation was found between DPP4 activity and BDNF, and this negative correlation was partly mediated by oxidative stress, not inflammation. The DBR was positively associated with MCI and thus may be used as a novel risk biomarker for MCI in an elderly population with normal glucose tolerance.
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影响因子：
3.7
作者：
Maimaiti Yisireyili;Kyosuke Takeshita;M. Hayashi;Hongxian Wu;Y. Uchida;Koji Yamamoto;R. Kikuchi;Chang-ning Hao;T. Nakayama;X. Cheng;T. Matsushita;S. Nakamura;T. Murohara
通讯作者：
Maimaiti Yisireyili;Kyosuke Takeshita;M. Hayashi;Hongxian Wu;Y. Uchida;Koji Yamamoto;R. Kikuchi;Chang-ning Hao;T. Nakayama;X. Cheng;T. Matsushita;S. Nakamura;T. Murohara
DOI：
10.1002/14651858.cd007220.pub2
发表时间：
2011-04
期刊：
The Cochrane database of systematic reviews
影响因子：
--
作者：
C. P. Ooi;S. Loke;Z. Yassin;T. Hamid
通讯作者：
C. P. Ooi;S. Loke;Z. Yassin;T. Hamid
肠促胰岛素轴在炎症性肠病中的作用
影响因子：
7.3
作者：
Duan L;Rao X;Braunstein Z;Toomey AC;Zhong J
通讯作者：
Zhong J
影响因子：
4.7
作者：
Abdelsalam, Rania M.;Safar, Marwa M.
通讯作者：
Safar, Marwa M.
影响因子：
--
作者：
Luchsinger, Jose A.;Reitz, Christiane;Mayeux, Richard
通讯作者：
Mayeux, Richard