The Effect of Anthocyanin-Rich Foods or Extracts on Vascular Function in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
The Effect of Anthocyanin-Rich Foods or Extracts on Vascular Function in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
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DOI：
10.3390/nu9080908
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发表时间：
2017-08-20
期刊：
影响因子：
5.9
通讯作者：
Hill AM
中科院分区：
文献类型：
--
作者：
Fairlie-Jones L;Davison K;Fromentin E;Hill AM
花色苷由于其抗氧化和血管舒张特性而受到关注。早期的评论表明，浆果和其他富含花青素的食物或提取物可以改善血管健康，但花青素对血管功能的影响尚未被审查。为了解决文献中的这一空白，我们对随机对照试验进行了系统回顾和荟萃分析，这些试验研究了富含花青素的食物或提取物对成人血管反应性和/或僵硬度的影响。将24项研究的数据合并为标准化平均差（SMD）和95%置信区间（CI）。花青素消耗显著改善急性（SMD：3.92%，95%CI：1.47，6.38，p = 0.002; I2 = 91.8%）和慢性补充（SMD：0.84%，95%CI：0.55，1.12，p = 0.000; I2 = 62.5%）后的血流介导的扩张（FMD）。仅在急性补充后，脉搏波速度有所改善（SMD：−1.27 m/s，95% CI：−1.96，−0.58，p = 0.000; I2 = 17.8%）。这些结果支持了先前综述的发现，即富含花青素的食物或提取物确实可以改善血管健康，特别是在FMD测量的血管反应性方面。需要更多的研究来确定最佳剂量和消费的长期影响。
Anthocyanins are of interest due to their anti-oxidative and vasodilatory properties. Earlier reviews have shown that berries and other anthocyanin rich foods or extracts can improve vascular health, however the effect of anthocyanins on vascular function has not yet been reviewed. To address this gap in the literature, we conducted a systematic review and meta-analysis of randomised-controlled trials examining anthocyanin-rich foods or extracts on measures of vascular reactivity and/or stiffness in adults. Data from 24 studies were pooled as standardized mean difference (SMD) with 95% confidence intervals (CI). Anthocyanin consumption significantly improved flow-mediated dilation (FMD) following acute (SMD: 3.92%, 95% CI: 1.47, 6.38, p = 0.002; I2 = 91.8%) and chronic supplementation (SMD: 0.84%, 95% CI: 0.55, 1.12, p = 0.000; I2 = 62.5%). Pulse wave velocity was improved following acute supplementation only (SMD: −1.27 m/s, 95% CI: −1.96, −0.58, p = 0.000; I2 = 17.8%). These results support the findings of previous reviews that anthocyanin rich foods or extracts may indeed improve vascular health, particularly with respect to vascular reactivity measured by FMD. More research is required to determine the optimal dosage, and the long-term effects of consumption.
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影响因子：
3.9
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