Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients.
Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients.
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慢性乙型肝炎患者胰岛β细胞功能显着下降与高血糖密切相关。
DOI：
10.1155/2021/1264707
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发表时间：
2021
影响因子：
2.8
通讯作者：
Tang H
中科院分区：
文献类型：
--
作者：
Liu D;Zhou L;Zhang X;Zeng Y;Bai L;Wu D;Tang H
本研究旨在探讨慢性B型肝炎（CH B）患者糖代谢和胰岛β细胞功能（HOMA-β）的特点及其危险因素。 本横断面研究招募了110例CH B患者（CH B组）和110例无B型肝炎病毒（non-HBV组）;在相同的糖代谢状态下，根据性别、年龄和体重指数进行匹配。分析两组患者的危险因素、特征、糖代谢及HOMA-β值的差异。 伴有肝硬化（LC）或B型肝炎包膜抗原（HBeAg）（-）状态的CH B患者糖代谢异常率较高。此外，在相同糖代谢状态下，CHB组空腹血糖（FPG）和餐后2 h血糖（2 h-PG）水平均高于非HBV组，HOMA-β值显著低于非HBV组，HOMA-IR值不高于非HBV组（均P < 0.0001）。进一步分析显示，糖代谢异常的主要危险因素是HBeAg（-）状态和B型肝炎包膜抗体水平。HBV血清学和病毒学指标对HOMA-β值无影响。 慢性B型肝炎患者胰岛β细胞功能受损，与慢性B型肝炎患者空腹及餐后高血糖密切相关。结论B病毒感染对胰岛β细胞功能有明显影响，其机制有待进一步研究。
This study is aimed at the characteristics of glucose metabolism and islet β cell function evaluated by the homeostasis model assessment of β cell function (HOMA-β) value and its risk factors in chronic hepatitis B (CHB) patients. This cross-sectional study recruited 110 CHB patients (CHB group) and 110 patients without hepatitis B virus (non-HBV group); the groups were matched according to sex, age, and body mass index under the same glucose metabolism status. The risk factors, characteristics, and differences in glucose metabolism and HOMA-β values between the two groups were analyzed. The abnormal glucose metabolism rate was higher in CHB patients with liver cirrhosis (LC) or hepatitis B envelope antigen (HBeAg) (−) status. In addition, under the same glucose metabolism status, the fasting plasma glucose (FPG) levels and 2-hour postprandial plasma glucose (2h-PG) levels in the CHB group were higher, while the HOMA-β values were significantly lower and the homeostasis model assessment of insulin resistance (HOMA-IR) value was not higher than that in the non-HBV group (all P < 0.0001). Further analyses revealed that the main risk factors for abnormal glucose metabolism were HBeAg (−) status and hepatitis B envelope antibody levels. But HBV serological and virological indicators had no effects on the HOMA-β values. Islet β cell function in patients with CHB was compromised, which is closely associated with fasting and postprandial hyperglycemia in chronic hepatitis B patients. Further research should be done to verify the compromised islet β cell function and then to investigate the mechanisms behind the effect of hepatitis B virus infection on islet β cell function in CHB patients.
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影响因子：
3.8
作者：
Klisic, Aleksandra;Kavaric, Nebojsa;Kotur-Stevuljevic, Jelena
通讯作者：
Kotur-Stevuljevic, Jelena
DOI：
10.1002/hep.30083
发表时间：
2018-10
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Pang Y;Kartsonaki C;Turnbull I;Guo Y;Clarke R;Chen Y;Bragg F;Yang L;Bian Z;Millwood IY;Hao J;Han X;Zang Y;Chen J;Li L;Holmes MV;Chen Z
通讯作者：
Chen Z
影响因子：
6.7
作者：
Shen, Yi;Zhang, Sheng;Liang, Feng
通讯作者：
Liang, Feng
影响因子：
2.5
作者：
Spradling, P. R.;Simons, B.;McMahon, B. J.
通讯作者：
McMahon, B. J.
影响因子：
12.8
作者：
Kim HY;Cho HK;Yoo SK;Cheong JH
通讯作者：
Cheong JH