Advances in translational neuropathic research: example of enantioselective pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief in complex regional pain syndrome.
Advances in translational neuropathic research: example of enantioselective pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief in complex regional pain syndrome.
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DOI：
10.1007/s11916-011-0185-3
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发表时间：
2011-06
影响因子：
3.7
通讯作者：
Goldberg ME
中科院分区：
文献类型：
--
作者：
Sabia M;Hirsh RA;Torjman MC;Wainer IW;Cooper N;Domsky R;Goldberg ME
历史上，复杂区域性疼痛综合征（CRPS）的定义不明确，这意味着科学家和临床医生在该综合征的研究、诊断和治疗方面面临着许多不确定性。该问题可归因于非特异性诊断标准，未知的病理生理原因和有限的治疗方案。这两种形式的CRPS仍然是痛苦的，使人衰弱的疾病，患者背负着沉重的情感负担。目前的研究表明，CRPS I和CRPS II是不同的过程，部分神经病变的存在或不存在将它们区分开来。氯胺酮一直是涉及治疗CRPS的各种研究的焦点；然而，目前，基于证据的研究数据不完整。至于为什么氯胺酮能有效控制一小部分CRPS患者的症状，而对其他患者无效，这个问题仍有待解答。对这一现象的一种可能解释是不同患者群体中可能存在的药物遗传差异。本文综述了近年来在氯胺酮治疗CRPS方面发表的重要转化研究成果。
Historically, complex regional pain syndrome (CRPS) was poorly defined, which meant that scientists and clinicians faced much uncertainty in the study, diagnosis, and treatment of the syndrome. The problem could be attributed to a nonspecific diagnostic criteria, unknown pathophysiologic causes, and limited treatment options. The two forms of CRPS still are painful, debilitating disorders whose sufferers carry heavy emotional burdens. Current research has shown that CRPS I and CRPS II are distinctive processes, and the presence or absence of a partial nerve lesion distinguishes them apart. Ketamine has been the focus of various studies involving the treatment of CRPS; however, currently, there is incomplete data from evidence-based studies. The question as to why ketamine is effective in controlling the symptoms of a subset of patients with CRPS and not others remains to be answered. A possible explanation to this phenomenon is pharmacogenetic differences that may exist in different patient populations. This review summarizes important translational work recently published on the treatment of CRPS using ketamine.
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影响因子：
5
作者：
Ebert, B;Mikkelsen, S;Borgbjerg, FM
通讯作者：
Borgbjerg, FM
影响因子：
3.1
作者：
Correll, GE;Maleki, J;Harbut, RE
通讯作者：
Harbut, RE
影响因子：
2
作者：
Kim, KJ;Yoon, YW;Chung, JM
通讯作者：
Chung, JM
影响因子：
7.4
作者：
BENNETT, GJ;XIE, YK
通讯作者：
XIE, YK
影响因子：
7.4
作者：
EIDE, PK;JORUM, E;BREIVIK, H
通讯作者：
BREIVIK, H