Decorin as a possible strategy for the amelioration of COVID-19.
Decorin as a possible strategy for the amelioration of COVID-19.
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DOI：
10.1016/j.mehy.2021.110612
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发表时间：
2021-07
影响因子：
4.7
通讯作者：
Bharani KK
中科院分区：
文献类型：
--
作者：
Allawadhi P;Singh V;Khurana I;Rawat PS;Renushe AP;Khurana A;Navik U;Allwadhi S;Kumar Karlapudi S;Banothu AK;Bharani KK
冠状病毒大流行已成为现代一场非同寻常的医疗危机。SARS-CoV-2新型冠状病毒传播率高，与以前已知的冠状病毒相比更具攻击性和毒性。它主要通过诱导引起全身炎症和肺纤维化的细胞因子风暴来攻击呼吸系统。Decorin是一种多能分子，属于富含亮氨酸的蛋白多糖群，在细胞外基质（ECM）组装中发挥关键作用，调节细胞生长、粘附、增殖、炎症和纤维形成。有趣的是，decorin具有有效的抗炎、细胞因子抑制和抗纤维生成作用，这使其成为对抗COVID-19相关并发症的潜在候选药物，特别是在肺纤维化的背景下。因此，我们认为由于其独特的药理作用和免疫调节作用，decorin可能成为治疗COVID-19的临床前治疗药物。
Coronavirus pandemic has emerged as an extraordinary healthcare crisis in modern times. The SARS-CoV-2 novel coronavirus has high transmission rate, is more aggressive and virulent in comparison to previously known coronaviruses. It primarily attacks the respiratory system by inducing cytokine storm that causes systemic inflammation and pulmonary fibrosis. Decorin is a pluripotent molecule belonging to a leucine rich proteoglycan group that exerts critical role in extracellular matrix (ECM) assembly and regulates cell growth, adhesion, proliferation, inflammation, and fibrogenesis. Interestingly, decorin has potent anti-inflammatory, cytokine inhibitory, and anti-fibrillogenesis effects which make it a potential drug candidate against the COVID-19 related complications especially in the context of lung fibrosis. Herein, we postulate that owing to its distinctive pharmacological actions and immunomodulatory effect, decorin can be a promising preclinical therapeutic agent for the therapy of COVID-19.
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影响因子：
64.8
作者：
BORDER, WA;NOBLE, NA;RUOSLAHTI, E
通讯作者：
RUOSLAHTI, E
影响因子：
5.5
作者：
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影响因子：
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作者：
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通讯作者：
Morrione, Andrea
DOI：
10.1083/jcb.200901129
发表时间：
2009-05-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
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通讯作者：
Iozzo RV
影响因子：
5.8
作者：
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通讯作者：
Birzniece, Vita