Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.
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DOI：
10.1016/j.immuni.2008.05.009
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发表时间：
2008-07-18
期刊：
影响因子：
32.4
通讯作者：
Dong, Chen
中科院分区：
文献类型：
--
作者：
Nurieva, Roza I.;Chung, Yeonseok;Hwang, Daehee;Yang, Xuexian O.;Kang, Hong Soon;Ma, Li;Wang, Yi-Hong;Watowich, Stephanie S.;Jetten, Anton M.;Tian, Qiang;Dong, Chen
激活后，尽管CXCR5+卵泡TH（TFH）细胞在体液中很重要，但CD4+辅助剂t（Th）细胞分化为不同的效应谱系。效应T细胞并在体内发展独立于Th1或Th2谱系。 Th17细胞的发展取决于IL-21，IL-6和STAT3，与TH17细胞不同，TFH细胞的分化不需要TGFβ信号传导或Th17特异性孤儿核受体RORα和RORα和RORγ在IL-21存在的情况下，在体外激活了细胞，但不是TGFβ信号传导优先获得TFH基因表达和功能，以促进体内生发中心反应因此，研究表明TFH是效应子分化的独特谱系。
After activation, CD4+ helper T (TH) cells differentiate into distinct effector lineages. Although CXCR5+ follicular TH (TFH) cells are important in humoral immunity, their developmental regulation is unclear. Here we show that TFH cells have a distinct gene expression profile from other effector T cells and develop in vivo independent of the TH1 or TH2 lineages. TFH cell generation is regulated by B7h expressed on B cells and, similar to TH17 cell development, is dependent on IL-21, IL-6 and STAT3. However, differentiation of TFH cells, unlike TH17 cells, does not require TGFβ signaling or TH17-specific orphan nuclear receptors RORα and RORγ in vivo. Finally, naïve T cells activated in vitro in the presence of IL-21 but not TGFβ signaling preferentially acquire TFH gene expression and function to promote germinal center reactions in vivo. This study thus demonstrates TFH as a distinct lineage of effector TH differentiation.
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