3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction.
3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction.
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DOI：
10.3390/pharmaceutics13122143
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发表时间：
2021-12-13
期刊：
影响因子：
5.4
通讯作者：
Uskoković P
中科院分区：
文献类型：
--
作者：
Jovanović M;Petrović M;Cvijić S;Tomić N;Stojanović D;Ibrić S;Uskoković P
采用半固态挤出3D打印技术制备了明胶-聚乙烯吡咯烷酮（PVP）和明胶-聚乙烯醇（PVA）口腔粘膜粘附膜。本研究的目的是评估合成聚合物PVP和PVA对明胶基膜的热性能和机械性能以及药物释放曲线的影响。傅里叶变换红外光谱表明，明胶和PVP之间的氢键在印刷过程中形成。在另一种共混物中，既没有PVA的酯化也没有明胶发生。差示扫描量热法显示存在部分螺旋结构。与这些结果一致，每种共混物的机械性能和药物释放曲线不同。明胶-PVP和PRH的制剂具有更高的拉伸强度、硬度和粘合强度，但比明胶-PVA和PRH的制剂药物释放更慢。计算机群体模拟表明，与速释片剂相比，药物生物利用度增加，所得药代动力学特征的个体间差异减少。此外，模拟结果表明，减少PRH每日剂量可以实现与缓释口腔膜，提高患者的依从性。
Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.
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发表时间：
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