MicroRNAs as potential signatures of environmental exposure or effect: a systematic review.
MicroRNAs as potential signatures of environmental exposure or effect: a systematic review.
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DOI：
10.1289/ehp.1408459
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发表时间：
2015-05
影响因子：
10.4
通讯作者：
Nawrot TS
中科院分区：
文献类型：
--
作者：
Vrijens K;Bollati V;Nawrot TS
背景：疾病组包括从产前开始影响健康的所有生命过程环境暴露。微小RNA（miRNAs）是这一概念中作为疾病的标志物和病因的有趣实体。MicroRNA是短的寡核苷酸序列，可以与几种mRNA靶相互作用。目的：我们回顾了该领域的现状，利用miRNA作为环境暴露的生物标志物的潜力。我们研究了响应于人类可能暴露于的所有类型的环境暴露的miRNA特征，包括香烟烟雾，空气污染，纳米颗粒和各种化学品;我们检查了已报告的已鉴定的miRNA的健康状况（即，心血管疾病、癌症和糖尿病）。方法：我们检索了PubMed和ScienceDirect数据库，以确定相关研究。结果：对于纳入本综述的所有暴露，27种miRNA在至少两项独立研究中差异表达。在多项研究中观察到的具有与吸烟相关的表达改变的miRNA是miR-21、miR-34 b、miR-125 b、miR-146 a、miR-223和miR-340;并且在多项空气污染研究中观察到的那些miRNA是miR-9、miR-10 b、miR-21、miR-128、miR-143、miR-155、miR-222、miR-223和miR-338。我们发现在体外、体内和人体研究中，miRNA和暴露之间几乎没有重叠。在这里，我们报告了在多项暴露研究中发现的这些miRNAs的疾病相关性。结论：miRNA的变化可能是急性和慢性环境暴露效应的敏感指标。因此，miRNA是有价值的新型暴露生物标志物。进一步的研究应该阐明miRNA在生命各个阶段的暴露和效应之间的介导作用，以提供对miRNA变化后果的更准确评估。引文：Vrijens K，Bollati V，Nawrot TS. 2015. MicroRNA作为环境暴露或影响的潜在特征：系统综述环境健康展望123：399-411; http：dx.doi.org/10.1289/ehp.1408459
Background: The exposome encompasses all life-course environmental exposures from the prenatal period onward that influence health. MicroRNAs (miRNAs) are interesting entities within this concept as markers and causation of disease. MicroRNAs are short oligonucleotide sequences that can interact with several mRNA targets. Objectives: We reviewed the current state of the field on the potential of using miRNAs as biomarkers for environmental exposure. We investigated miRNA signatures in response to all types of environmental exposure to which a human can be exposed, including cigarette smoke, air pollution, nanoparticles, and diverse chemicals; and we examined the health conditions for which the identified miRNAs have been reported (i.e., cardiovascular disease, cancer, and diabetes). Methods: We searched the PubMed and ScienceDirect databases to identify relevant studies. Results: For all exposures incorporated in this review, 27 miRNAs were differentially expressed in at least two independent studies. miRNAs that had expression alterations associated with smoking observed in multiple studies are miR-21, miR-34b, miR-125b, miR-146a, miR-223, and miR-340; and those miRNAs that were observed in multiple air pollution studies are miR-9, miR-10b, miR-21, miR-128, miR-143, miR-155, miR-222, miR-223, and miR-338. We found little overlap among in vitro, in vivo, and human studies between miRNAs and exposure. Here, we report on disease associations for those miRNAs identified in multiple studies on exposure. Conclusions: miRNA changes may be sensitive indicators of the effects of acute and chronic environmental exposure. Therefore, miRNAs are valuable novel biomarkers for exposure. Further studies should elucidate the role of the mediation effect of miRNA between exposures and effect through all stages of life to provide a more accurate assessment of the consequences of miRNA changes. Citation: Vrijens K, Bollati V, Nawrot TS. 2015. MicroRNAs as potential signatures of environmental exposure or effect: a systematic review. Environ Health Perspect 123:399–411; http://dx.doi.org/10.1289/ehp.1408459
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