Total and individual antioxidant intake and risk of epithelial ovarian cancer.
Total and individual antioxidant intake and risk of epithelial ovarian cancer.
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DOI：
10.1186/1471-2407-12-211
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发表时间：
2012-06-01
期刊：
影响因子：
3.8
通讯作者：
Bandera EV
中科院分区：
文献类型：
--
作者：
Gifkins D;Olson SH;Paddock L;King M;Demissie K;Lu SE;Kong AN;Rodriguez-Rodriguez L;Bandera EV
限制卵巢上皮的氧化应激已被提议作为对抗卵巢癌的一线防御。尽管个体膳食抗氧化剂摄入量与卵巢癌风险之间存在关联的证据相互矛盾，但综合证据表明存在适度的负相关。我们的研究旨在评估总抗氧化能力（TAC）和个体抗氧化剂摄入量（维生素C，维生素E，β-胡萝卜素，硒，叶黄素和番茄红素）与卵巢癌风险之间的关系。我们在新泽西进行了一项基于人群的病例对照研究。病例为居住在新泽西六个县的21岁及以上新诊断的上皮性卵巢癌妇女。对照组是居住在同一地理区域的相同年龄范围的妇女。共纳入205例卵巢癌病例和390例对照。膳食摄入量确定使用块食物频率问卷（FFQ），和TAC指数的构建通过连接FFQ衍生的估计两个标准化的抗氧化能力数据库，美国农业部氧自由基吸收能力（ORAC）数据库，和奥尔索大学的抗氧化剂食品数据库。在控制主要卵巢癌危险因素的同时，使用多变量逻辑回归模型计算比值比和95%置信区间。我们发现与食物来源的硒有很强的负相关性（OR：0.41; 95%CI：0.20-0.85，饮食硒摄入量的最高与最低三分位数）。然而，几乎没有证据表明与饮食中的TAC或其他抗氧化剂有关。相比之下，与非使用者相比，补充剂使用者对所有微量营养素的风险都显着增加，但从食物和补充剂中摄入任何这些抗氧化剂的风险没有统计学显着增加。这项研究发现，食物来源的硒摄入量与卵巢癌风险之间存在负相关关系，而几乎没有证据表明与TAC或任何其他抗氧化剂有关。需要进一步的研究来证实这些发现。
Limiting oxidative stress to the ovarian epithelium has been proposed as a first-line defense against ovarian cancer. Although evidence for an association between individual dietary antioxidant intake and ovarian cancer risk is conflicting, the combined evidence suggests a modest inverse association. Our study aimed to evaluate the association between total antioxidant capacity (TAC) and individual antioxidant intakes (vitamin C, vitamin E, beta-carotene, selenium, lutein, and lycopene) and ovarian cancer risk. We conducted a population-based case–control study in New Jersey. Cases were women ages 21 years and older with newly diagnosed epithelial ovarian cancer who resided in six counties of New Jersey. Controls were women in the same age range who resided in the same geographic area. A total of 205 ovarian cancer cases and 390 controls were included. Dietary intake was ascertained using the Block food frequency questionnaire (FFQ), and TAC indices were constructed by linking FFQ-derived estimates to two standardized antioxidant capacity databases, the USDA Oxygen Radical Absorbance Capacity (ORAC) Database, and the University of Olso’s Antioxidant Food Database. Multivariate logistic regression models were used to calculate odds ratios and 95 % confidence intervals while controlling for major ovarian cancer risk factors. We found a strong inverse association with selenium from food sources (OR: 0.41; 95 % CI: 0.20-0.85, for the highest vs. lowest tertile of dietary selenium intake). However, there was little evidence of an association with dietary TAC or the others individual antioxidants. In contrast, compared to non-users, supplement users had significant increased risk for all micronutrients, but no statistically significant increased risk was observed for combined intake from foods and supplements of any of these antioxidants. This study found an inverse association between selenium consumption from food sources and ovarian cancer risk, while there was little evidence of an association with TAC or any of the other individual antioxidants. Additional research is needed to confirm these findings.
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影响因子：
2.9
作者：
ENGLE, A;MUSCAT, JE;HARRIS, RE
通讯作者：
HARRIS, RE
影响因子：
4.2
作者：
McCann, SE;Freudenheim, JL;Graham, S
通讯作者：
Graham, S
DOI：
10.1158/1055-9965.epi-08-0936
发表时间：
2009-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Fortuny J;Sima C;Bayuga S;Wilcox H;Pulick K;Faulkner S;Zauber AG;Olson SH
通讯作者：
Olson SH
影响因子：
2.3
作者：
Bandera, Elisa V.;Williams, Melony G.;Sima, Camelia;Bayuga, Sharon;Pulick, Katherine;Wilcox, Homer;Soslow, Robert;Zauber, Ann G.;Olson, Sara H.
通讯作者：
Olson, Sara H.
影响因子：
2.9
作者：
Fleischauer, AT;Olson, SH;Harlap, S
通讯作者：
Harlap, S