Phytoestrogen consumption and endometrial cancer risk: a population-based case-control study in New Jersey.
Phytoestrogen consumption and endometrial cancer risk: a population-based case-control study in New Jersey.
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DOI：
10.1007/s10552-009-9336-9
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发表时间：
2009-09
影响因子：
2.3
通讯作者：
Olson, Sara H.
中科院分区：
文献类型：
--
作者：
Bandera, Elisa V.;Williams, Melony G.;Sima, Camelia;Bayuga, Sharon;Pulick, Katherine;Wilcox, Homer;Soslow, Robert;Zauber, Ann G.;Olson, Sara H.
植物雌激素已被证明在某些组织（包括乳腺）中发挥抗雌激素和雌激素作用。然而，只有少数研究评估了它们在子宫内膜癌风险中的作用。我们在新泽西进行的一项基于人群的病例对照研究中评估了这种关联。共有424例和398对照完成了采访，包括食物频率问卷补充问题的植物雌激素食品。风险评估采用非条件Logistic回归，调整子宫内膜癌的主要危险因素。有迹象表明摄入槲皮素可降低风险（OR：0.65; 95% CI：0.41-1.01，最高四分位数与最低四分位数相比;趋势p：0.02）。我们发现有限的证据与任何评估的木脂素，总木脂素，香豆雌酚，个人的甾酮，总甾酮，或总植物雌激素的关联。然而，有一些建议表明，仅限于瘦女性（BMI <25）（最高三分位数的OR：0.50，95% CI：0.25-0.98）和腰臀比≤0.85的女性（OR：0.59; 95% CI：0.33-1.05），总的卡路里摄入量呈负相关。没有证据表明HRT的使用会改变疗效。这项研究表明，瘦女性摄入槲皮素和维生素B1可降低患子宫内膜癌的风险。
Phytoestrogens have been shown to exert anti-estrogenic and estrogenic effects in some tissues, including the breast. However, only a few studies have evaluated their role in endometrial cancer risk. We evaluated this association in a population-based case-control study in New Jersey. A total of 424 cases and 398 controls completed an interview, including a food frequency questionnaire with supplemental questions for phytoestrogen foods. Risk estimates were derived using unconditional logistic regression, adjusting for major risk factors for endometrial cancer. There was some suggestion of a decreased risk with quercetin intake (OR: 0.65; 95% CI: 0.41–1.01 for the highest compared to the lowest quartile; p for trend: 0.02). We found limited evidence of an association with any of the lignans evaluated, total lignans, coumestrol, individual isoflavones, total isoflavones, or total phytoestrogens. However, there was some suggestion of an inverse association with total isoflavone intake limited to lean women (BMI <25) (OR for the highest tertile: 0.50, 95% CI: 0.25–0.98) and those with a waist-to-hip ratio ≤0.85 (OR: 0.59; 95% CI: 0.33–1.05). There was no evidence of effect modification by HRT use. This study suggests a reduction in endometrial cancer risk with quercetin intake and with isoflavone intake in lean women.
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DOI：
10.1093/jnci/djg015
发表时间：
2003-08-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Horn-Ross, PL;John, EM;Lee, MM
通讯作者：
Lee, MM
影响因子：
7.1
作者：
Setchell, KDR
通讯作者：
Setchell, KDR
影响因子：
2.3
作者：
Garcia-Closas, R;Gonzalez, CA;Riboli, E
通讯作者：
Riboli, E
影响因子：
5
作者：
Lin, Jennifer;Zhang, Shumin M.;Giovannucci, Edward
通讯作者：
Giovannucci, Edward
影响因子：
2.3
作者：
Littman, AJ;Beresford, SAA;White, E
通讯作者：
White, E