Simultaneous three-dimensional myocardial T1 and T2 mapping in one breath hold with 3D-QALAS.
Simultaneous three-dimensional myocardial T1 and T2 mapping in one breath hold with 3D-QALAS.
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DOI：
10.1186/s12968-014-0102-0
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发表时间：
2014-12-20
期刊：
影响因子：
--
通讯作者：
Ebbers T
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文献类型：
--
作者：
Kvernby S;Warntjes MJ;Haraldsson H;Carlhäll CJ;Engvall J;Ebbers T
心肌纵向和横向松弛时间的量化在心脏诊断中提供了重要的信息。心脏松弛时间标测的方法通常需要长时间屏气来测量单个2D切片中的T1或T2。在这篇文章中，我们提出并评价了一种新的方法，在15次心跳的一次屏气内对整个左心室心肌进行3D交错T1和T2标测。3D-QALAS(使用具有T2准备脉冲的交织Look-Locker获取序列的3D量化)基于使用具有交织T2准备的反转恢复的3D损坏的Turbo场回波序列。通过对纵向磁化强度Mz的模拟，从5次测量中获得了分辨率为2.0×2.0×6.0 mm的13个切片的T1和T2的量化。该捕获方案被重复三次以采样k空间。该方法在体外(针对反转恢复和多回声验证)和体内(针对Molli和Dual Echo验证)进行了评估。在体外，3D-QALAS与反转恢复(R=0.998；N=10；P<；0.01)以及3D-QALAS与多回声(R=0.996；N=10；P<；0.01)有很强的相关性。3D-QALAS方法显示，例如，在40-120 bpm的间隔内不依赖心率。健康心肌3D-QALAS和Molli的T1值分别为1083±43ms和1089±54ms，T2值分别为50.4±3.6ms和50.3±3.5ms。在10名健康志愿者中，3D-QALAS和Molli(N=10；p=0.65)和Dual Echo(N=10；p=0.925)的体内松弛时间没有显著差异。3D-QALAS方法在体外和体内都表现出良好的准确性和扫描内可变性。它允许快速获取，并在同一扫描中提供T1和T2松弛时间的定量信息，全面覆盖左心室，使临床能够应用于更广泛的心脏疾病。
Quantification of the longitudinal- and transverse relaxation time in the myocardium has shown to provide important information in cardiac diagnostics. Methods for cardiac relaxation time mapping generally demand a long breath hold to measure either T1 or T2 in a single 2D slice. In this paper we present and evaluate a novel method for 3D interleaved T1 and T2 mapping of the whole left ventricular myocardium within a single breath hold of 15 heartbeats. The 3D-QALAS (3D-quantification using an interleaved Look-Locker acquisition sequence with T2 preparation pulse) is based on a 3D spoiled Turbo Field Echo sequence using inversion recovery with interleaved T2 preparation. Quantification of both T1 and T2 in a volume of 13 slices with a resolution of 2.0x2.0x6.0 mm is obtained from five measurements by using simulations of the longitudinal magnetizations Mz. This acquisition scheme is repeated three times to sample k-space. The method was evaluated both in-vitro (validated against Inversion Recovery and Multi Echo) and in-vivo (validated against MOLLI and Dual Echo). In-vitro, a strong relation was found between 3D-QALAS and Inversion Recovery (R = 0.998; N = 10; p < 0.01) and between 3D-QALAS and Multi Echo (R = 0.996; N = 10; p < 0.01). The 3D-QALAS method showed no dependence on e.g. heart rate in the interval of 40–120 bpm. In healthy myocardium, the mean T1 value was 1083 ± 43 ms (mean ± SD) for 3D-QALAS and 1089 ± 54 ms for MOLLI, while the mean T2 value was 50.4 ± 3.6 ms 3D-QALAS and 50.3 ± 3.5 ms for Dual Echo. No significant difference in in-vivo relaxation times was found between 3D-QALAS and MOLLI (N = 10; p = 0.65) respectively 3D-QALAS and Dual Echo (N = 10; p = 0.925) for the ten healthy volunteers. The 3D-QALAS method has demonstrated good accuracy and intra-scan variability both in-vitro and in-vivo. It allows rapid acquisition and provides quantitative information of both T1 and T2 relaxation times in the same scan with full coverage of the left ventricle, enabling clinical application in a broader spectrum of cardiac disorders.
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DOI：
10.2214/ajr.05.1264
发表时间：
2006-12-01
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Sparrow, Patrick;Messroghli, Daniel R;Sivananthan, Mohan U
通讯作者：
Sivananthan, Mohan U
影响因子：
3.3
作者：
Huang, Teng-Yi;Liu, Yi-Jui;Poncelet, Brigitte P.
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Poncelet, Brigitte P.
影响因子：
3.3
作者：
Coniglio, A.;Di Renzi, P.;Begnozzi, L.
通讯作者：
Begnozzi, L.
前对比T1和T2 CMR检测到的心肌水肿描述了与急性心肌梗塞相关的风险。
影响因子：
14
作者：
Ugander, Martin;Bagi, Paul S.;Oki, Abiola J.;Chen, Billy;Hsu, Li-Yueh;Aletras, Anthony H.;Shah, Saurabh;Greiser, Andreas;Kellman, Peter;Arai, Andrew E.
通讯作者：
Arai, Andrew E.
心肌T1和T2映射在3 t：参考值，影响因素和含义。
DOI：
10.1186/1532-429x-15-53
发表时间：
2013-06-18
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
von Knobelsdorff-Brenkenhoff F;Prothmann M;Dieringer MA;Wassmuth R;Greiser A;Schwenke C;Niendorf T;Schulz-Menger J
通讯作者：
Schulz-Menger J