Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction.
Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction.
复制标题
前对比T1和T2 CMR检测到的心肌水肿描述了与急性心肌梗塞相关的风险。
DOI：
10.1016/j.jcmg.2012.01.016
复制
发表时间：
2012-06
影响因子：
14
通讯作者：
Arai, Andrew E.
中科院分区：
文献类型：
--
作者：
Ugander, Martin;Bagi, Paul S.;Oki, Abiola J.;Chen, Billy;Hsu, Li-Yueh;Aletras, Anthony H.;Shah, Saurabh;Greiser, Andreas;Kellman, Peter;Arai, Andrew E.
确定与微球或 T2 映射 CMR 相比，心脏磁共振 (CMR) 体内 T1 映射是否可以测量危险心肌面积 (AAR)。如果由于心肌缺血相关水肿导致 AAR 中 T2 加权 CMR 异常，那么 T1 加权 CMR 也应该能够检测并准确量化 AAR。狗 (n=9) 接受 2 小时的冠状动脉闭塞，然后进行 4 小时的再灌注。在给予任何造影剂之前，对左心室进行 CMR 以绘制 T1 和 T2 图。 AAR 被定义为 T1 或 T2 值 (ms) 大于远程 2SD 的区域，以及闭塞期间微球血流量 (ml/min/g) 小于远程 2SD 的区域。通过氯化三苯基四唑染色测定梗塞大小。与远端心肌相比，AAR 中的松弛参数 T1 和 T2 有所增加（T1：1133±55 vs. 915±33ms，T2：71±6 vs. 49±3 ms；平均值±SD）。在逐个切片的基础上（n=78 个切片），T1 和 T2 映射的 AAR 相关（R2=0.95，p<0.001），具有良好的一致性（切片的 0.4±16.6%，平均值±2SD）。在全心分析中，左心室质量、AAR 和心肌挽救的 T1 测量值与微球测量值相关 (R2=0.94)，具有良好的一致性（心肌 -1.4±11.2 g；平均值±2SD）。左心室质量、AAR 和挽救的相应 T2 测量与微球分析相关（R2=0.96，心肌一致性为 1.6±9.2 g；平均值±2SD）。中位梗死面积为 AAR 的 30%（范围 12-52）。为了确定急性心肌梗塞后的危险区域，非对比 T1 映射和 T2 映射序列产生相似的定量结果，并且两者都与微球吻合良好。松弛特性 T1 和 T2 的变化方式与心肌缺血/再灌注后心肌水肿的存在一致。
To determine whether cardiac magnetic resonance (CMR) in vivo T1-mapping can measure myocardial area at risk (AAR) compared with microspheres or T2-mapping CMR. If T2-weighted CMR is abnormal in the AAR due to edema related to myocardial ischemia, then T1-weighted CMR should also be able to detect and accurately quantify AAR. Dogs (n=9) underwent a 2 hour coronary occlusion followed by 4 hours of reperfusion. CMR of the left ventricle was performed for mapping of T1 and T2 prior to any contrast administration. AAR was defined as regions which had a T1 or T2 value (ms) greater than 2SD from remote, and regions with microsphere blood flow (ml/min/g) during occlusion less than 2SD from remote. Infarct size was determined by triphenyltetrazolium chloride staining. The relaxation parameters T1 and T2 were increased in the AAR compared to remote myocardium (T1: 1133±55 vs. 915±33ms, T2: 71±6 vs. 49±3 ms; mean±SD). On a slice-by-slice basis (n=78 slices), AAR by T1- and T2-mapping correlated (R2=0.95, p<0.001) with good agreement (0.4±16.6 % of slice, mean±2SD). On a whole-heart analysis, T1 measurements of left ventricular mass, AAR and myocardial salvage correlated to microsphere measures (R2=0.94) with good agreement (−1.4±11.2 g of myocardium; mean±2SD). Corresponding T2 measurements of left ventricular mass, AAR, and salvage correlated to microsphere analysis (R2=0.96, agreement 1.6±9.2 g of myocardium; mean±2SD). Median infarct size was 30% of the AAR (range 12–52). For determining area at risk after acute myocardial infarction, non-contrast T1-mapping and T2-mapping sequences yield similar quantitative results, and both agree well with microspheres. The relaxation properties T1 and T2 both change in a way that is consistent with the presence of myocardial edema following myocardial ischemia/reperfusion.
登录
查看更多内容
DOI：
10.1186/1532-429x-13-13
发表时间：
2011-02-18
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Eitel I;Friedrich MG
通讯作者：
Friedrich MG
影响因子：
10.8
作者：
GARCIADORADO, D;OLIVERAS, J;SOLERSOLER, J
通讯作者：
SOLERSOLER, J
影响因子：
37.8
作者：
Aletras, AH;Tilak, GS;Arai, AE
通讯作者：
Arai, AE
影响因子：
4.8
作者：
BROWN, JJ;PECK, WW;SLUTSKY, RA
通讯作者：
SLUTSKY, RA
影响因子：
4.4
作者：
Hsu, LY;Natanzon, A;Arai, AE
通讯作者：
Arai, AE