Role of Wnt1 and Fzd1 in the spinal cord pathogenesis of amyotrophic lateral sclerosis-transgenic mice
Role of Wnt1 and Fzd1 in the spinal cord pathogenesis of amyotrophic lateral sclerosis-transgenic mice
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Wnt1和Fzd1在肌萎缩侧索硬化症转基因小鼠脊髓发病机制中的作用
DOI：
10.1007/s10529-013-1199-1
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发表时间：
2013-04
影响因子：
2.7
通讯作者：
Wang, Xin
中科院分区：
文献类型：
--
作者：
Zhang, Caixia;Yu, Li;Zhou, Fenghua;Wang, Xin
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by chronic progressive degeneration of motor neurons resulting in muscular atrophy, paralysis, and ultimately death. We have investigated the expression of Wnt1 and Fzd1 in the spinal cords of SOD1G93A ALS transgenic mice, SOD1G93A-transfected N2a cells, and primary cultured astrocytes from SOD1G93A transgenic mice. In addition, we provided further insight into the role of Wnt1 and Fzd1 in the pathogenesis of ALS transgenic mice and discuss the mechanisms underlying the Wnt signal pathway which may be useful in the treatment of ALS. The results indicate the involvement of Wnt1 and Fzd1 in the pathogenesis and development of ALS.
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影响因子：
15.1
作者：
Che HV;Metzger S;Portal E;Deyle C;Riess O;Nguyen HP
通讯作者：
Nguyen HP
影响因子：
64.8
作者：
Brian M. Owens
通讯作者：
Brian M. Owens
影响因子：
15.1
作者：
L'episcopo F;Serapide MF;Tirolo C;Testa N;Caniglia S;Morale MC;Pluchino S;Marchetti B
通讯作者：
Marchetti B
DOI：
10.53347/rid-70821
发表时间：
2019-09
期刊：
Radiopaedia.org
影响因子：
--
作者：
Rohit Sharma;Y. Voss
通讯作者：
Rohit Sharma;Y. Voss
影响因子：
56.9
作者：
J. Marx
通讯作者：
J. Marx