Paroxysmal Symptoms As the First Manifestation of Multiple Sclerosis Mimicking a Transient Ischemic Attack: A Report of Two Cases.
Paroxysmal Symptoms As the First Manifestation of Multiple Sclerosis Mimicking a Transient Ischemic Attack: A Report of Two Cases.
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DOI：
10.3389/fneur.2017.00585
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发表时间：
2017
影响因子：
3.4
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Zhang Y;Fan S;Han F;Xu Y
阵发性症状是多发性硬化症(MS)的罕见表现。当以阵发性症状为首发临床表现时，很容易被误认为短暂性脑缺血发作(TIA)。此前，有几例报告有阵发性症状的多发性硬化症被误诊为TIA。在这里，我们报告另外两个病例，集中于MS的阵发性症状的临床特征。这两个病例都以阵发性症状为首发症状；一个表现为一过性头晕、左侧面部麻木和右肢无力，另一个表现为发作性头晕、视力模糊、恶心、心悸和站立时颤抖。根据经颅多普勒记录的微栓子信号，这两名患者的症状最初都被误认为TIA，但后来根据神经影像和腰椎穿刺术被正确诊断为MS。发作症状对卡马西平有反应，静脉注射甲基强的松龙和干扰素后症状完全缓解。在此，我们旨在总结MS和TIA的发作性症状之间的差异，以便于及时的鉴别诊断和建议早期适当的治疗。
Paroxysmal symptoms are unusual manifestations of multiple sclerosis (MS). When presented as the first clinical manifestation, paroxysmal symptoms may easily be mistaken for transient ischemic attack (TIA). Previously, several cases of MS that reported with paroxysmal symptoms were misdiagnosed as TIA. Here, we report two additional cases, focusing on the clinical characteristics of paroxysmal symptoms in MS. Both cases had paroxysmal symptoms as their first manifestation; one presented with transient dizziness, left face numbness, and right limb weakness, and the other presented with episodic lightheadedness, blurred vision, nausea, palpitations, and tremulousness upon standing. Both of the patients’ symptoms were mistaken for TIA at first, based on microembolic signals recorded by transcranial Doppler, but were later correctly diagnosed with MS based on neuroimaging and lumbar puncture. The paroxysmal symptoms responded to carbamazepine and were relieved completely after administration of intravenous methylprednisolone and interferon. Herein, we aim to summarize the differences between paroxysmal symptoms seen in MS and TIA, to facilitate a timely differential diagnosis and recommend an early appropriate treatment.
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影响因子：
11
作者：
MATTHEWS, WB
通讯作者：
MATTHEWS, WB
影响因子：
4.4
作者：
Xu, Yan;Wang, Qian;Cui, Li-ying
通讯作者：
Cui, Li-ying
影响因子：
3.5
作者：
Tanzi, A.;Onorato, E.;Anzola, G. P.
通讯作者：
Anzola, G. P.
影响因子：
0.9
作者：
Yates, T J V;Crawley, F
通讯作者：
Crawley, F
影响因子：
9.9
作者：
ANDERMANN, F;COSGROVE, JBR;WALTERS, AM
通讯作者：
WALTERS, AM