Urinary saturation and risk factors for calcium oxalate stone disease based on spot and 24-hour urine specimens.
Urinary saturation and risk factors for calcium oxalate stone disease based on spot and 24-hour urine specimens.
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基于现场和 24 小时尿液样本的尿饱和度和草酸钙结石病的危险因素。
DOI：
--
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
K. Sugaya
中科院分区：
文献类型：
--
作者：
Y. Ogawa;H. Yonou;S. Hokama;M. Oda;M. Morozumi;K. Sugaya
222例随机点尿标本中，结石患者的钙浓度和草酸钙饱和度[DG(CaOx)]明显高于非结石患者，而柠檬酸盐和肌酐校正后的柠檬酸盐浓度则较低。在188份24小时尿液标本中，结石患者的镁排泄量低于非结石患者，而肌酐校正的钙浓度和DG（CaOx）较高。在结石患者中，尿中钙、草酸盐、柠檬酸盐、镁和DG（CaOx）的浓度没有性别差异，但肌酐校正的钙、柠檬酸盐和镁浓度在女性中较高，24小时柠檬酸盐排泄量也较高。钙和草酸盐水平对DG（CaOx）有主要影响，而柠檬酸盐和镁水平的影响较小。DG（CaOx）与钙和草酸排泄量以及肌酐校正的钙和草酸浓度相关。约5%的24小时尿液标本表现为临界过饱和，80%表现为亚稳态过饱和，15%为不饱和。高钙尿或高草酸尿在严重过饱和尿中相当常见（30%和40%），而在亚稳态过饱和尿中较少见（22.4%和8.6%），在不饱和尿中未检测到。在任何饱和度下，低尿和/或低镁尿更为常见（63.8-80%）。尿钙、草酸盐和柠檬酸盐浓度，以及肌酐校正的钙、草酸盐、柠檬酸盐和镁浓度和DG(CaOx)，在57对晨尿和24小时尿标本之间显示出显著的相关性。晨尿标本中肌酐校正的钙和柠檬酸盐浓度与配对的24小时尿液标本中钙和柠檬酸盐排泄水平显著相关。综上所述，除了尿饱和度之外，没有其他参数能模糊地指示出结石发生的风险，因此，无论是清晨尿液还是24小时尿液标本中的DG（CaOx）似乎都是结石风险的最佳预测指标。最后，晨尿中肌酐校正的钙和柠檬酸盐浓度可作为测量24小时排泄量的替代。
In 222 random spot urine specimens, the calcium concentration and calcium oxalate saturation [DG(CaOx)] were significantly higher among stone formers than among non-stone formers, while the citrate and creatinine-corrected citrate concentrations were lower. In 188 24-hour urine specimens, magnesium excretion was lower among stone formers than non-stone formers, while the creatinine-corrected calcium concentration and DG(CaOx) were higher. Among stone formers, there was no gender difference in the urinary concentrations of calcium, oxalate, citrate, magnesium, and DG(CaOx), but the creatinine-corrected calcium, citrate, and magnesium concentrations were higher in women, as well as 24-hour citrate excretion. The levels of calcium and oxalate have a major influence on DG(CaOx), while citrate and magnesium levels have a minor influence. DG(CaOx) was correlated with calcium and oxalate excretion, as well as with the creatinine-corrected calcium and oxalate concentrations. Approximately 5% of 24-hour urine specimens showed critical supersaturation, 80% showed metastable supersaturation, and 15% were unsaturated. Hypercalciuria or hyperoxaluria was fairly common (30% and 40%) in critically supersaturated urine, while it was less common (22.4% and 8.6%) in metastably supersaturated urine and was not detected in unsaturated urine. Hypocitraturia and/or hypomagnesiuria was more common (63.8-80%) at any saturation. The urinary calcium, oxalate, and citrate concentrations, as well as the creatinine-corrected calcium, oxalate, citrate, and magnesium concentrations and DG(CaOx), showed a significant correlation between 57 paired early morning spot urine and 24-hour urine specimens. The creatinine-corrected calcium and citrate concentrations of the early morning urine specimens were significantly correlated with the levels of calcium and citrate excretion in the paired 24-hour urine specimens. In conclusion, no parameter other than urinary saturation gives more than a vague indication of the risk of lithogenesis, so DG(CaOx) in either early morning urine or 24-hour urine specimens appears to be the best predictor of stone risk. Finally, the creatinine-corrected calcium and citrate concentrations in early morning urine can be used as a substitute for measuring 24-hour excretion.
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影响因子：
19.6
作者：
Parks, JH;Coward, M;Coe, FL
通讯作者：
Coe, FL
肾结石患者泌尿系统危险因素的季节性变化。
DOI：
--
发表时间：
1991
期刊：
The Journal of lithotripsy & stone disease
影响因子：
--
作者：
StuartRO2nd;Hill,K;Poindexter,J;Pak,CY
通讯作者：
Pak,CY
影响因子：
6.6
作者：
PREMINGER, GM;SAKHAEE, K;PAK, CYC
通讯作者：
PAK, CYC
影响因子：
39.2
作者：
R. Wortmann;I. Fox
通讯作者：
R. Wortmann;I. Fox
影响因子：
19.6
作者：
Curhan, GC;Willett, WC;Stampfer, MJ
通讯作者：
Stampfer, MJ