Molecular Epidemiology of Rubella Virus Strains Detected Around the Time of the 2012-2013 Epidemic in Japan.
Molecular Epidemiology of Rubella Virus Strains Detected Around the Time of the 2012-2013 Epidemic in Japan.
复制标题
DOI：
10.3389/fmicb.2017.01513
复制
发表时间：
2017
影响因子：
5.2
通讯作者：
Takeda M
中科院分区：
文献类型：
--
作者：
Mori Y;Miyoshi M;Kikuchi M;Sekine M;Umezawa M;Saikusa M;Matsushima Y;Itamochi M;Yasui Y;Kanbayashi D;Miyoshi T;Akiyoshi K;Tatsumi C;Zaitsu S;Kadoguchi M;Otsuki N;Okamoto K;Sakata M;Komase K;Takeda M
2012年至2013年，日本发生了全国性的风疹流行，导致约1.7万例风疹病例，45名患有先天性风疹综合征的婴儿出生。本研究的目的是对日本流行期间流行的风疹病毒（RVs）进行遗传表征。对2010 - 2014年在日本14个县检测到的221株RV病毒E1基因739个核苷酸窗口区进行了测序。根据系统发育分析，按时间和地理将病毒毒株分为不同的组。221株菌株中，2B、1E、1J基因型分别为192株（87%）、26株（12%）和3株（1%）。大多数（184）株2B基因型菌株属于2B- l1谱系，与东南亚和东亚国家的菌株具有核苷酸同源性。系统发育分析表明，2010年至2014年间，至少有6个不同的RV毒株聚集性（聚集性1-6）在日本引发了疫情。其中，聚集性3、4、6株在2012-2013年几乎同时传播。聚集性3株在当地传播，而聚集性4株在全国传播。调查结果表明，rv是从邻国多次引入日本的。2012-2013年的疫情是由至少三个RV毒株聚集引起的复杂疫情。
A nationwide rubella epidemic occurred from 2012 to 2013 in Japan, resulting in around 17,000 rubella cases and the birth of 45 infants with congenital rubella syndrome. The aim of this study was to genetically characterize the rubella viruses (RVs) circulating around the time of the epidemic in Japan. In total, 221 RV strains detected from 14 prefectures in Japan between 2010 and 2014 were sequenced in the 739 nucleotide-window region within the E1 gene. The virus strains were chronologically and geographically characterized into groups based on phylogenetic analysis. Among the 221 strains analyzed, 192 (87%), 26 (12%), and 3 (1%) strains were classified into genotypes 2B, 1E, and 1J, respectively. The majority (n = 184) of the genotype 2B strains belonged to lineage 2B-L1 and shared nucleotide homology with the strains detected in Southeast and East Asian countries. Phylogenetic analyses demonstrated that at least six distinct clusters of RV strains (clusters 1–6) induced outbreaks in Japan between 2010 and 2014. Among them, strains from clusters 3, 4, and 6 circulated almost simultaneously during 2012–2013. The cluster 3 strains circulated locally, whereas strains from cluster 4 spread nationwide. The findings suggest that RVs were introduced into Japan many times from neighboring countries. The 2012–2013 epidemic was a complex of outbreaks induced by at least three clusters of RV strains.
登录
查看更多内容
影响因子：
10.7
作者：
TAMURA, K;NEI, M
通讯作者：
NEI, M
影响因子：
8.8
作者：
Van Hung Pham;Thong Van Nguyen;Abe, Kenji
通讯作者：
Abe, Kenji
影响因子：
33.9
作者：
Grant, Gavin B.;Reef, Susan E.;Strebel, Peter M.
通讯作者：
Strebel, Peter M.
影响因子：
5.5
作者：
Otsuki, Noriyuki;Abo, Hitoshi;Komase, Katsuhiro
通讯作者：
Komase, Katsuhiro
影响因子：
5.4
作者：
WOLINSKY, JS;MCCARTHY, M;SIMMONS, D
通讯作者：
SIMMONS, D