Comparison of children with onset of juvenile dermatomyositis symptoms before or after their fifth birthday in a UK and Ireland juvenile dermatomyositis cohort study.
Comparison of children with onset of juvenile dermatomyositis symptoms before or after their fifth birthday in a UK and Ireland juvenile dermatomyositis cohort study.
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DOI：
10.1002/acr.21753
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发表时间：
2012-11
影响因子：
4.7
通讯作者：
Wedderburn, L. R.
中科院分区：
文献类型：
--
作者：
Martin, N.;Krol, P.;Smith, S.;Beard, L.;Pilkington, C. A.;Davidson, J.;Wedderburn, L. R.
比较两组青少年皮肌炎 (DM) 儿童（即在五岁生日前出现症状的儿童与在五岁生日或之后开始发病的儿童），并评估发病年龄是否与疾病表现、接受的治疗或诊断后 2 年结果的差异相关。对招募参加英国青少年糖尿病队列研究的儿童进行数据分析，这些儿童被诊断为可能或明确的青少年糖尿病，并且诊断和招募之间的时间间隔不到 12 个月。 157 名儿童中有 55 名 (35%) 在五岁生日之前出现症状。诊断时，年轻组中 32.7% 发现皮肤溃疡，而老年组中这一比例为 11.8% (P = 0.003)。年轻组更常报告面部或身体肿胀，而老年组更常报告头痛、脱发和雷诺现象。两年后的随访中，各组之间的结果没有显着差异。两组中超过 90% 的患者同时接受甲氨蝶呤和类固醇治疗。诊断后 2 年后，两组中都有 23% 的人仍继续使用类固醇。我们的研究表明，5 岁以下发病的青少年糖尿病儿童更有可能出现溃疡性皮肤病和水肿。两组之间的结果没有临床显着差异。
To compare 2 groups of children with juvenile dermatomyositis (DM), those with onset of symptoms before their fifth birthday versus those whose disease begins either on or after their fifth birthday, and to assess whether age at onset is associated with differences in disease presentation, treatments received, or outcomes 2 years after diagnosis. Data were analyzed on children recruited to a UK juvenile DM cohort study with a diagnosis of probable or definite juvenile DM and less than 12 months between diagnosis and recruitment. Fifty-five (35%) of 157 children had onset of symptoms before their fifth birthday. At diagnosis, cutaneous ulceration was found in 32.7% of the younger group versus 11.8% of the older group (P = 0.003). Facial or body swelling was reported more often in the younger group, whereas headaches, alopecia, and Raynaud's phenomenon were all more frequently reported in the older group. At followup 2 years later, there were no important differences in outcomes between the groups. More than 90% of patients in both groups received both methotrexate and steroids. Twenty-three percent of both groups remained on steroids 2 years after diagnosis. Our study showed that children with juvenile DM with disease onset at age <5 years are more likely to present with ulcerative skin disease and edema. There were no clinically significant differences in outcomes between the 2 groups.
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影响因子：
4.7
作者：
Rider, Lisa G.;Koziol, Deloris;Giannini, Edward H.;Jain, Minal S.;Smith, Michaele R.;Whitney-Mahoney, Kristi;Feldman, Brian M.;Wright, Susan J.;Lindsley, Carol B.;Pachman, Lauren M.;Villalba, Maria L.;Lovell, Daniel J.;Bowyer, Suzanne L.;Plotz, Paul H.;Miller, Frederick W.;Hicks, Jeanne E.
通讯作者：
Hicks, Jeanne E.
影响因子：
5.5
作者：
Martin, Neil;Krol, Petra;Wedderburn, Lucy R.
通讯作者：
Wedderburn, Lucy R.
影响因子：
5.5
作者：
Maillard, SM;Jones, R;Murray, KJ
通讯作者：
Murray, KJ
影响因子：
5.5
作者：
Brown, V. E.;Pilkington, C. A.;Davidson, J. E.
通讯作者：
Davidson, J. E.
DOI：
10.1002/art.23340
发表时间：
2008-02-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Huber, Adam M.;Dugan, Elizabeth M.;Rider, Lisa G.
通讯作者：
Rider, Lisa G.