The immunologic profile of adoptively transferred lymphocytes influences stroke outcome of recipients.
The immunologic profile of adoptively transferred lymphocytes influences stroke outcome of recipients.
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DOI：
10.1016/j.jneuroim.2013.07.014
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发表时间：
2013-10-15
影响因子：
3.3
通讯作者：
Becker, Kyra
中科院分区：
文献类型：
--
作者：
Zierath, Dannielle;Schulze, Juliane;Kunze, Allison;Drogomiretskiy, Olga;Derek Nhan;Jaspers, Brett;Dressel, Alexander;Becker, Kyra
Animals that have myelin basic protein (MBP) specific lymphocytes with a Th1(+) phenotype have worse stroke outcome than those that do not. Whether these MBP specific cells contribute to worsened outcome or are merely a consequence of worse outcome is unclear. In these experiments, lymphocytes were obtained from donor animals one month after stroke and transferred to naïve recipient animals at the time of cerebral ischemia. The MBP specific phenotype of donor cells was determined prior to transfer. Animals that received either MBP specific Th1(+) or Th17(+) cells experienced worse neurological outcome, and the degree of impairment correlated with the robustness of MBP specific Th1(+) and Th17(+) responses. These data demonstrate that the immunologic phenotype of antigen specific lymphocytes influences stroke outcome.
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影响因子：
5.8
作者：
Jansson, A;Ernerudh, J;Vrethem, M
通讯作者：
Vrethem, M
影响因子：
3.7
作者：
Vogelgesang A;May VE;Grunwald U;Bakkeboe M;Langner S;Wallaschofski H;Kessler C;Bröker BM;Dressel A
通讯作者：
Dressel A
影响因子：
8.3
作者：
BEDERSON, JB;PITTS, LH;BARTKOWSKI, H
通讯作者：
BARTKOWSKI, H
DOI：
10.1097/00004647-199911000-00010
发表时间：
1999-11-01
影响因子：
6.3
作者：
Suzuki, S;Tanaka, K;Fukuuchi, Y
通讯作者：
Fukuuchi, Y
影响因子：
8.3
作者：
Krupinski, J;Kumar, P;Kaluza, J
通讯作者：
Kaluza, J