Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations.
Synchronous Seasonality in the Gut Microbiota of Wild Mouse Populations.
复制标题
DOI：
10.3389/fmicb.2022.809735
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
Knowles, Sarah C. L.
中科院分区：
文献类型：
--
作者：
Marsh, Kirsty J.;Raulo, Aura M.;Brouard, Marc;Troitsky, Tanya;English, Holly M.;Allen, Bryony;Raval, Rohan;Venkatesan, Saudamini;Pedersen, Amy B.;Webster, Joanne P.;Knowles, Sarah C. L.
肠道微生物组在哺乳动物宿主中执行许多重要功能，群落组成塑造其功能作用。然而，驱动野生动物个体微生物群变异的因素以及这些变异在多大程度上是可预测的或在种群中具有特异性的，仍然知之甚少。在这里，我们使用来自一种常见啮齿动物物种（木鼠，Apodemus sylvaticus）的多种群数据集来测试在该物种中是否可以识别一致的“核心”肠道微生物群，以及微生物群变化的预测因子在多大程度上在种群间是一致的。在2014年至2018年期间，我们使用捕获标记再捕获和16 S rRNA分析来集中监测两个野生木鼠种群及其肠道微生物群，以及表征来自同一物种实验室饲养的菌落的微生物群。尽管在高分类水平上微生物群大致相似，但这两个野生种群并没有共享一个单一的细菌扩增子序列变体（ASV），尽管相距仅50公里。与此同时，实验室居住的殖民地与一个野生种群共享许多ASV，据信它是几十年前建立的。尽管没有共享任何ASV，但这两个野生种群共享的微生物群在遗传学上比任何一个与殖民地的微生物群更相似，并且预测每个野生种群组成变化的因素非常相似。我们确定了一种强烈而一致的季节性微生物群重组模式，这种模式发生在两个地点，在所有年份和个体小鼠中。虽然微生物群高度个性化，但在冬末/早春发生了一些季节性收敛。这些发现揭示了该物种多个种群中高度可重复的季节性肠道微生物群动态，尽管涉及不同的分类群。这为未来的工作提供了一个平台，以了解这种可预测的季节性微生物重组的驱动因素和功能意义，包括它是否可能为宿主提供适应性季节性表型可塑性。
The gut microbiome performs many important functions in mammalian hosts, with community composition shaping its functional role. However, the factors that drive individual microbiota variation in wild animals and to what extent these are predictable or idiosyncratic across populations remains poorly understood. Here, we use a multi-population dataset from a common rodent species (the wood mouse, Apodemus sylvaticus), to test whether a consistent “core” gut microbiota is identifiable in this species, and to what extent the predictors of microbiota variation are consistent across populations. Between 2014 and 2018 we used capture-mark-recapture and 16S rRNA profiling to intensively monitor two wild wood mouse populations and their gut microbiota, as well as characterising the microbiota from a laboratory-housed colony of the same species. Although the microbiota was broadly similar at high taxonomic levels, the two wild populations did not share a single bacterial amplicon sequence variant (ASV), despite being only 50km apart. Meanwhile, the laboratory-housed colony shared many ASVs with one of the wild populations from which it is thought to have been founded decades ago. Despite not sharing any ASVs, the two wild populations shared a phylogenetically more similar microbiota than either did with the colony, and the factors predicting compositional variation in each wild population were remarkably similar. We identified a strong and consistent pattern of seasonal microbiota restructuring that occurred at both sites, in all years, and within individual mice. While the microbiota was highly individualised, some seasonal convergence occurred in late winter/early spring. These findings reveal highly repeatable seasonal gut microbiota dynamics in multiple populations of this species, despite different taxa being involved. This provides a platform for future work to understand the drivers and functional implications of such predictable seasonal microbiome restructuring, including whether it might provide the host with adaptive seasonal phenotypic plasticity.
登录
查看更多内容
DOI：
10.1038/nri3535
发表时间：
2013-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
1.9
作者：
Fogel, Andrew T.
通讯作者：
Fogel, Andrew T.
影响因子：
16.6
作者：
de Muinck EJ;Trosvik P
通讯作者：
Trosvik P
影响因子：
4.6
作者：
Funosas G;Triadó-Margarit X;Castro F;Villafuerte R;Delibes-Mateos M;Rouco C;Casamayor EO
通讯作者：
Casamayor EO