Predicting Severity and Intrahospital Mortality in COVID-19: The Place and Role of Oxidative Stress.
Predicting Severity and Intrahospital Mortality in COVID-19: The Place and Role of Oxidative Stress.
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DOI：
10.1155/2021/6615787
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发表时间：
2021
影响因子：
--
通讯作者：
Jakovljevic V
中科院分区：
文献类型：
--
作者：
Cekerevac I;Turnic TN;Draginic N;Andjic M;Zivkovic V;Simovic S;Susa R;Novkovic L;Mijailovic Z;Andjelkovic M;Vukicevic V;Vulovic T;Jakovljevic V
SARS-CoV-2病毒引起感染，导致2020年全球大流行，发展为严重急性呼吸系统综合征。因此，本研究旨在研究其在预测COVID-19严重程度和院内死亡率方面的可能作用，以及其他实验室和生化程序，临床体征，症状和合并症。本研究经克拉古耶瓦茨临床中心伦理委员会批准，设计为一项观察性前瞻性横断面临床研究，于2020年4月至8月对127名确诊呼吸道COVID-19病毒感染的患者进行了研究。主要目标是确定COVID-19严重程度的预测因素，并确定COVID-19感染阴性结果的预测因素。所有患者被分为三类：轻度、中度和重度COVID-19感染患者。所有的生化和实验室程序都在入院的第一天完成。重症COVID-19患者入院时的呼吸（p < 0.001）和心脏（p = 0.002）率显著较高。在所有观察到的血液学和炎症标志物中，只有白色血细胞计数（9.43 ± 4.62，p = 0.001）和LDH（643.13 ± 313.3，p = 0.002）在重度COVID-19组中显著较高。我们已经观察到，在严重形式的SARS-CoV-2中，超氧阴离子自由基的水平显著高于其他两组（11.3 ± 5.66，p < 0.001），而严重疾病患者的一氧化氮水平显著低于其他两组（2.66 ± 0.45，p < 0.001）。使用线性回归模型，TA，嗅觉丧失，味觉丧失，O2−和ICU持续时间被估计为SARS-CoV-2疾病严重程度的预测因子。呼吸困难和心率加快被证实为阴性、致死性结局的预测因素。我们的研究结果表明，高血压、嗅觉丧失和味觉丧失的存在，以及ICU住院时间和血清O2−水平是COVID-19严重程度的预测因素，而呼吸困难和入院时心率增加是COVID-19死亡率的预测因素。
SARS-CoV-2 virus causes infection which led to a global pandemic in 2020 with the development of severe acute respiratory syndrome. Therefore, this study was aimed at examining its possible role in predicting severity and intrahospital mortality of COVID-19, alongside with other laboratory and biochemical procedures, clinical signs, symptoms, and comorbidity. This study, approved by the Ethical Committee of Clinical Center Kragujevac, was designed as an observational prospective cross-sectional clinical study which was conducted on 127 patients with diagnosed respiratory COVID-19 viral infection from April to August 2020. The primary goals were to determine the predictors of COVID-19 severity and to determine the predictors of the negative outcome of COVID-19 infection. All patients were divided into three categories: patients with a mild form, moderate form, and severe form of COVID-19 infection. All biochemical and laboratory procedures were done on the first day of the hospital admission. Respiratory (p < 0.001) and heart (p = 0.002) rates at admission were significantly higher in patients with a severe form of COVID-19. From all observed hematological and inflammatory markers, only white blood cell count (9.43 ± 4.62, p = 0.001) and LDH (643.13 ± 313.3, p = 0.002) were significantly higher in the severe COVID-19 group. We have observed that in the severe form of SARS-CoV-2, the levels of superoxide anion radicals were substantially higher than those in two other groups (11.3 ± 5.66, p < 0.001) and the nitric oxide level was significantly lower in patients with the severe disease (2.66 ± 0.45, p < 0.001). Using a linear regression model, TA, anosmia, ageusia, O2−, and the duration at the ICU are estimated as predictors of severity of SARS-CoV-2 disease. The presence of dyspnea and a higher heart rate were confirmed as predictors of a negative, fatal outcome. Results from our study show that presence of hypertension, anosmia, and ageusia, as well as the duration of ICU stay, and serum levels of O2− are predictors of COVID-19 severity, while the presence of dyspnea and an increased heart rate on admission were predictors of COVID-19 mortality.
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影响因子：
3.6
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DOI：
10.1186/s12941-020-00362-2
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