Safety and Prognostic Impacts of Ovarian Preservation during Radical Hysterectomy for Early-Stage Adenocarcinoma and Adenosquamous Cervical Cancer.
Safety and Prognostic Impacts of Ovarian Preservation during Radical Hysterectomy for Early-Stage Adenocarcinoma and Adenosquamous Cervical Cancer.
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DOI：
10.1155/2020/5791381
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发表时间：
2020
影响因子：
--
通讯作者：
Leetanaporn K
中科院分区：
文献类型：
--
作者：
Theplib A;Hanprasertpong J;Leetanaporn K
明确卵巢转移的发生率以及保留卵巢对早期腺癌和腺鳞癌宫颈癌肿瘤学结局的影响。 281例IA 2-IB 1期腺癌和腺鳞癌宫颈癌患者接受了广泛子宫切除术和盆腔淋巴结切除术（RHND）。对173例在RHND期间接受卵巢切除术的患者的卵巢转移发生率进行了评估。对年龄小于50岁的患者（281例患者中的196例）进行亚组分析，将其分为两组，卵巢保留组和非卵巢保留组。5-对两组患者的5年无复发生存率（5年RFS）和5年总生存率（5年OS）进行评价和比较。 随访期间没有卵巢转移、同步性卵巢癌或卵巢复发的证据。在小于50岁的患者中，卵巢保留组和非卵巢保留组之间的5年RFS（P = 0.363）或5年OS（P = 0.974）无统计学显著差异。在Kaplan-Meier分析中，在长期随访（15年后）中，卵巢保留组的OS似乎略好;但差异无统计学意义。 卵巢保留在腺癌和腺鳞癌宫颈癌阶段IA2-B1是安全的。然而，卵巢保留对肿瘤结局的影响需要进一步研究。
To identify the incidence of ovarian metastasis and the impact of ovarian preservation on oncological outcomes for early-stage adenocarcinoma and adenosquamous cervical cancer. 281 patients with stages IA2-IB1 adenocarcinoma and adenosquamous cervical cancer who underwent radical hysterectomy with pelvic lymphadenectomy (RHND) were included in the study. The incidence of ovarian metastasis was evaluated from 173 patients who underwent oophorectomy during RHND. Subgroup analysis was performed for patients less than 50 years (196 of 281 patients) who were classified into two groups, ovarian preservation and nonovarian preservation groups. 5-year recurrence-free survival (5-yr RFS) and 5-year overall survival (5-yr OS) were evaluated and compared between these groups. There was no evidence of ovarian metastasis, synchronous ovarian cancer, or ovarian recurrence during follow-up. In patients less than 50 years of age, there were no statistically significant differences in the 5-yr RFS (P = 0.363), or 5-yr OS (P = 0.974) between the ovarian preservation and nonovarian preservation groups. In Kaplan–Meier analysis, the ovarian preservation group seemed to have a slightly better OS in long-term follow-up (after 15 years); however, the difference was not statistically significant. Ovarian preservation was safe in adenocarcinoma and adenosquamous cervical cancer stages IA2-B1. However, the impact of ovarian preservation on oncological outcomes needs to be further investigated.
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影响因子：
120.7
作者：
Manson, JoAnn E.;Chlebowski, Rowan T.;Stefanick, Marcia L.;Aragaki, Aaron K.;Rossouw, Jacques E.;Prentice, Ross L.;Anderson, Garnet;Howard, Barbara V.;Thomson, Cynthia A.;LaCroix, Andrea Z.;Wactawski-Wende, Jean;Jackson, Rebecca D.;Limacher, Marian;Margolis, Karen L.;Wassertheil-Smoller, Sylvia;Beresford, Shirley A.;Cauley, Jane A.;Eaton, Charles B.;Gass, Margery;Hsia, Judith;Johnson, Karen C.;Kooperberg, Charles;Kuller, Lewis H.;Lewis, Cora E.;Liu, Simin;Martin, Lisa W.;Ockene, Judith K.;O'Sullivan, Mary Jo;Powell, Lynda H.;Simon, Michael S.;Van Horn, Linda;Vitolins, Mara Z.;Wallace, Robert B.
通讯作者：
Wallace, Robert B.
影响因子：
4.7
作者：
Smith, HO;Tiffany, MF;Key, CR
通讯作者：
Key, CR
DOI：
10.1016/s0735-1097(02)02763-8
发表时间：
2003-02-05
影响因子：
24
作者：
Merz, CNB;Johnson, BD;Sopko, G
通讯作者：
Sopko, G
影响因子：
7.2
作者：
Kato, I;Toniolo, P;Zeleniuch-Jacquotte, A
通讯作者：
Zeleniuch-Jacquotte, A
影响因子：
4.7
作者：
KLEINE, W;RAU, K;PFLEIDERER, A
通讯作者：
PFLEIDERER, A