Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection.
Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection.
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DOI：
10.1111/imr.12709
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发表时间：
2018-11
影响因子：
8.7
通讯作者：
Belz GT
中科院分区：
文献类型：
--
作者：
Almeida FF;Jacquelot N;Belz GT
免疫系统的研究已经从单纯的先天和适应性两种截然不同的观点转变为高度复杂的观点，并重塑了我们对如何确保健康稳定状态的看法。现在很清楚，免疫细胞并不完全适合这两种流，免疫稳态依赖于先天（包括树突状细胞、先天淋巴细胞和非常规淋巴细胞）和适应性（T淋巴细胞和B淋巴细胞）臂的多个谱系之间的持续对话，以及宿主和微生物之间的精细协调协同，这对确保免疫稳态至关重要。先天淋巴样细胞是这一新景观的关键参与者。在这里，我们讨论了最近的研究，这些研究详细阐明了ilc从其最早的祖细胞发展而来，并研究了影响其识别和驱动免疫稳态和长期免疫保护能力的因素。
The study of the immune system has shifted from a purely dichotomous separation between the innate and adaptive arms to one that is now highly complex and reshaping our ideas of how steady‐state health is assured. It is now clear that immune cells do not neatly fit into these two streams and immune homeostasis depends on continual dialogue between multiple lineages of the innate (including dendritic cells, innate lymphoid cells, and unconventional lymphocytes) and adaptive (T and B lymphocytes) arms together with a finely tuned synergy between the host and microbes which is essential to ensure immune homeostasis. Innate lymphoid cells are critical players in this new landscape. Here, we discuss recent studies that have elucidated in detail the development of ILCs from their earliest progenitors and examine factors that influence their identification and ability to drive immune homeostasis and long‐term immune protection.
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影响因子：
30.5
作者：
Cortez VS;Ulland TK;Cervantes-Barragan L;Bando JK;Robinette ML;Wang Q;White AJ;Gilfillan S;Cella M;Colonna M
通讯作者：
Colonna M
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
32.4
作者：
Califano D;Cho JJ;Uddin MN;Lorentsen KJ;Yang Q;Bhandoola A;Li H;Avram D
通讯作者：
Avram D
影响因子：
4.4
作者：
Adachi, S;Yoshida, H;Nishikawa, S
通讯作者：
Nishikawa, S
影响因子：
30.5
作者：
Bernink, Jochem H.;Peters, Charlotte P.;Spits, Hergen
通讯作者：
Spits, Hergen