Disrupted causal connectivity in mesial temporal lobe epilepsy.
Disrupted causal connectivity in mesial temporal lobe epilepsy.
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DOI：
10.1371/journal.pone.0063183
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lu G
中科院分区：
文献类型：
--
作者：
Ji GJ;Zhang Z;Zhang H;Wang J;Liu DQ;Zang YF;Liao W;Lu G
颞叶内侧癫痫（mTLE）虽然以颞叶内侧的病理改变为特征，但颞叶外侧也存在功能改变。我们的目的是研究癫痫致痫区（EZ）和其他脑区之间的信息流。记录了23例左侧mTLE患者和匹配对照组的静息状态功能磁共振成像（RS-fMRI）数据。首先利用RS-fMRI信号的低频波动幅度（ALFF）识别潜在EZ，然后对EZ与全脑进行逐体素的格兰杰因果关系分析。相对于对照组，患者表现出从EZ到丘脑和基底神经节的驱动作用降低，反馈增加。此外，我们发现EZ和皮层网络（默认模式网络，边缘系统，视觉网络和执行控制网络）之间的因果关系改变。EZ对右侧楔前叶和脑干的影响与病程呈负相关，而右侧海马、梭状皮质和豆状核对EZ的影响与病程呈正相关。这些发现表明，广泛的大脑区域显示与EZ的异常功能相互作用。此外，在患者中，EZ的ALFF增加与EZ的驱动效应增加呈正相关，但在对照组中则不相关。这一发现表明，癫痫活动的启动不仅取决于EZ本身，而且还取决于大规模宏观大脑网络中出现的活动。总的来说，这项研究表明，因果拓扑组织在mTLE中断，提供有价值的信息，了解这种疾病的病理生理。
Although mesial temporal lobe epilepsy (mTLE) is characterized by the pathological changes in mesial temporal lobe, function alteration was also found in extratemporal regions. Our aim is to investigate the information flow between the epileptogenic zone (EZ) and other brain regions. Resting-state functional magnetic resonance imaging (RS-fMRI) data were recorded from 23 patients with left mTLE and matched controls. We first identified the potential EZ using the amplitude of low-frequency fluctuation (ALFF) of RS-fMRI signal, then performed voxel-wise Granger causality analysis between EZ and the whole brain. Relative to controls, patients demonstrated decreased driving effect from EZ to thalamus and basal ganglia, and increased feedback. Additionally, we found an altered causal relation between EZ and cortical networks (default mode network, limbic system, visual network and executive control network). The influence from EZ to right precuneus and brainstem negatively correlated with disease duration, whereas that from the right hippocampus, fusiform cortex, and lentiform nucleus to EZ showed positive correlation. These findings demonstrate widespread brain regions showing abnormal functional interaction with EZ. In addition, increased ALFF in EZ was positively correlated with the increased driving effect on EZ in patients, but not in controls. This finding suggests that the initiation of epileptic activity depends not only on EZ itself, but also on the activity emerging in large-scale macroscopic brain networks. Overall, this study suggests that the causal topological organization is disrupted in mTLE, providing valuable information to understand the pathophysiology of this disorder.
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影响因子：
82.9
作者：
Cope, David W.;Di Giovanni, Giuseppe;Fyson, Sarah J.;Orban, Gergely;Errington, Adam C.;Lorincz, Magor L.;Gould, Timothy M.;Carter, David A.;Crunelli, Vincenzo
通讯作者：
Crunelli, Vincenzo
影响因子：
5.6
作者：
Bonilha L;Edwards JC;Kinsman SL;Morgan PS;Fridriksson J;Rorden C;Rumboldt Z;Roberts DR;Eckert MA;Halford JJ
通讯作者：
Halford JJ
影响因子：
14.5
作者：
Guye, Maxime;Regis, Jean;Bartolomei, Fabrice
通讯作者：
Bartolomei, Fabrice
影响因子：
3.7
作者：
GEWEKE, JF
通讯作者：
GEWEKE, JF
影响因子：
4.8
作者：
Alessio, Andrea;Pereira, Fabricio R. S.;Cendes, Fernando
通讯作者：
Cendes, Fernando