Targeting the Pentose Phosphate Pathway in Syndrome X-related Cardiovascular Complications.
Targeting the Pentose Phosphate Pathway in Syndrome X-related Cardiovascular Complications.
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DOI：
10.1002/ddr.20359
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发表时间：
2010-05-01
影响因子：
3.8
通讯作者：
Gupte, Sachin A.
中科院分区：
文献类型：
--
作者：
Gupte, Sachin A.
关键词：
X综合征是几种已知心血管危险因素（包括向心性肥胖、血脂异常、脂肪肝、高胰岛素血症、胰岛素抵抗和高血压）的组合或同时出现，在发达国家至少影响五分之一的人。 X 综合征会导致糖尿病和心血管疾病的发生，从而缩短寿命并增加发病率。全球约有 1.7 亿人患有 1 型或 2 型糖尿病，而且这些数字正在迅速上升。糖尿病患者的血管疾病发病较早，且进展速度加快。最近发现，葡萄糖-6-磷酸脱氢酶（G6PD）是戊糖磷酸途径中的限速酶，其反应产物在调节血管功能中发挥着关键作用。流行病学研究还表明，G6PD 缺乏症可显着降低某些地中海地区男性因心血管疾病引起的视网膜病变和死亡率。相反，G6PD 表达和活性在肥胖、高血糖和高胰岛素血症的大鼠和小鼠模型中上调，并且已提出 G6PD 在 2 型糖尿病胰岛素抵抗发展中的作用。不幸的是，没有选择性药物可以验证 G6PD 及其产品与人类 X 综合征的发生有关的假设。这篇综述讨论了 G6PD 与 X 综合征血管疾病相关的潜在机制，以及开发新方法（包括新药物和分子工具）来改善糖尿病引起的血管功能障碍和血管病变的必要性。
Syndrome X is a combination or co-occurrence of several known cardiovascular risk factors (including central obesity, dyslipidemias, fatty liver disease, hyperinsulinemia, insulin resistance, and hypertension) that affects at least one in five people in developed countries. Syndrome X shortens life and increases morbidity by contributing to the development of both diabetes and cardiovascular disease. Type 1 or 2 diabetes affects approximately 170 million people globally and these numbers are rapidly rising. In patients with diabetes, vascular diseases develop early and progress at an accelerated rate. It has recently become evident that glucose-6-phosphate dehydrogenase (G6PD), the rate limiting enzyme in the pentose-phosphate pathway and its reaction products play key roles in regulating vascular function. Epidemiological studies have also shown that G6PD deficiency markedly reduces retinopathy and mortality due to cardiovascular diseases in males from certain Mediterranean regions. Conversely, G6PD expression and activity are upregulated in rat and mouse models of obesity, hyperglycemia and hyperinsulinemia, and a role for G6PD in the development of insulin resistance in type 2 diabetes has been proposed. Unfortunately, there are no selective drugs available to validate the hypothesis that G6PD and its products are involved in the development of Syndrome X in humans. This review discusses the potential mechanisms by which G6PD could be implicated in vascular diseases in Syndrome X and the need to develop new approaches, including new drugs and molecular tools, to ameliorate diabetes-induced vascular dysfunction and vasculopathies.
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影响因子：
37.8
作者：
Matsui, R;Xu, SQ;Cohen, RA
通讯作者：
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Gupte, Sachin A.
DOI：
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