Software tools for cell culture-related 3D printed structures.
Software tools for cell culture-related 3D printed structures.
复制标题
DOI：
10.1371/journal.pone.0203203
复制
发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Czirok A
中科院分区：
文献类型：
--
作者：
Gulyas M;Csiszer M;Mehes E;Czirok A
三维（3D）打印技术允许在许多行业领域快速廉价地制造原型，它也成为生命科学中日益通用的实验平台。然而，控制打印机硬件的通用软件工具对于生物打印应用来说往往是次优的。在这里，我们报告了我们专门为满足生物打印要求而开发的开源软件工具包：机器运动可以（i）使用高级编程语言精确指定，（ii）轻松分布在一批组织培养皿中。为了证明所报道的技术的实用性，我们提出了定制制造的生物相容性3D打印塑料结构，该结构可以控制细胞扩散面积或介质体积，并且即使在50 μ l样品体积下也表现出优异的光学特性。我们希望我们的软件工具不仅有助于制造定制的体外实验室，而且还有助于涉及打印细胞和细胞外基质的应用。
Three-dimensional (3D) printing technology allowed fast and cheap prototype fabrication in numerous segments of industry and it also became an increasingly versatile experimental platform in life sciences. Yet, general purpose software tools to control printer hardware are often suboptimal for bioprinting applications. Here we report a package of open source software tools that we developed specifically to meet bioprinting requirements: Machine movements can be (i) precisely specified using high level programming languages, and (ii) easily distributed across a batch of tissue culture dishes. To demonstrate the utility of the reported technique, we present custom fabricated, biocompatible 3D-printed plastic structures that can control cell spreading area or medium volume, and exhibit excellent optical properties even at 50 ul sample volumes. We expect our software tools to be helpful not only to manufacture customized in vitro experimental chambers, but for applications involving printing cells and extracellular matrices as well.
登录
查看更多内容
影响因子：
3
作者：
Wardyn, Joanna D.;Sanderson, Chris;Stagi, Massimiliano
通讯作者：
Stagi, Massimiliano
影响因子：
41.2
作者：
通讯作者：
--
影响因子：
16.6
作者：
Laronda MM;Rutz AL;Xiao S;Whelan KA;Duncan FE;Roth EW;Woodruff TK;Shah RN
通讯作者：
Shah RN
影响因子：
8.9
作者：
Rusling JF
通讯作者：
Rusling JF
影响因子：
3.3
作者：
Czoendoer, Katalin;Ellwanger, Kornelia;Schlett, Katalin
通讯作者：
Schlett, Katalin