Jinkui Shenqi Pills Ameliorate Asthma with "Kidney Yang Deficiency" by Enhancing the Function of the Hypothalamic-Pituitary-Adrenal Axis to Regulate T Helper 1/2 Imbalance.
Jinkui Shenqi Pills Ameliorate Asthma with "Kidney Yang Deficiency" by Enhancing the Function of the Hypothalamic-Pituitary-Adrenal Axis to Regulate T Helper 1/2 Imbalance.
复制标题
金匮肾气丸通过增强下丘脑-垂体-肾上腺轴调节T辅助1/2失衡的功能改善“肾阳虚”哮喘
DOI：
10.1155/2018/7253240
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Shou QY
中科院分区：
文献类型：
--
作者：
Ji B;Li YY;Yang WJ;Zhang LZ;Fang MS;Fu HY;Shou QY
The aim of the study was to investigate the effects and underlying mechanism of JKSQP in a rat model of asthma with kidney-yang deficiency (KYD). Materials and Methods. Hydrocortisone (HYD) was used to establish the rat model of KYD; rats were then sensitized and challenged with ovalbumin (OVA). JKSQP was administered to OVA-challenged rats, and the changes in signs and symptoms of KYD were observed. The leukocyte number and subpopulations in bronchoalveolar lavage fluid (BALF) were counted and the cells were stained with Wright–Giemsa dye. Serum adrenocorticotropic hormone (ACTH), corticosterone (CORT), corticotropin-releasing hormone (CRH), total immunoglobulin E (IgE), and OVA-specific IgE levels were determined using relevant enzyme-linked immunosorbent assays (ELISA) kits. Results. JKSQP not only reversed the phenomenon of KYD but also significantly inhibited the number of leukocyte and eosinophils in the BALF, increasing the level of interferon (IFN)-γ and decreasing the levels of interleukin-4 (IL-4) and IgE in the serum compared with the OVA-challenged groups. Conclusions. Taken together, the antiasthma effects of JKSQP were likely mediated by the enhancement of the function of the hypothalamic-pituitary-adrenal axis and the reversal of T helper 1/2 imbalance.
登录
查看更多内容
DOI：
10.1155/2013/125943
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Chen HY;Lin YH;Thien PF;Chang SC;Chen YC;Lo SS;Yang SH;Chen JL
通讯作者：
Chen JL
DOI：
10.1155/2013/540957
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Zhao L;Wu H;Qiu M;Sun W;Wei R;Zheng X;Yang Y;Xin X;Zou H;Chen T;Liu J;Lu L;Su J;Ma C;Zhao A;Jia W
通讯作者：
Jia W
影响因子：
6.1
作者：
Yao, X. J.;Huang, K. W.;Ying, S.
通讯作者：
Ying, S.
DOI：
10.1016/j.chemolab.2013.09.001
发表时间：
2014-01-15
影响因子：
3.9
作者：
Zhang, Liangxiao;Han, Xiaofei;Xiao, Hongbin
通讯作者：
Xiao, Hongbin
影响因子：
5.4
作者：
Yang, Jianxiong;Wang, Yali;Guo, Juan
通讯作者：
Guo, Juan