Diarylethene-modified nucleotides for switching optical properties in DNA.
Diarylethene-modified nucleotides for switching optical properties in DNA.
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DOI：
10.3762/bjoc.8.103
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发表时间：
2012
影响因子：
2.7
通讯作者：
Wagenknecht HA
中科院分区：
文献类型：
--
作者：
Barrois S;Wagenknecht HA
二亚乙烯连接到2 ' -脱氧尿苷的5位上，以产生三种不同的光致变色核苷。对所有核苷的吸收和光致变色性质进行了表征。基于这些结果，利用自动磷酰胺化学将最有希望的光致变色DNA碱基修饰纳入到具有代表性的寡核苷酸中。DNA中光学性质的切换可以选择性地在310 nm（正向）和450 nm（反向）处实现；这两个波长都在正常核酸吸收范围之外。此外，这种核苷被证明是光化学稳定的，可以来回切换几次。这些结果为在dna结构中使用二芳烯作为光致变色化合物开辟了道路。
Diarylethenes were attached to the 5-position of 2’-deoxyuridine in order to yield three different photochromic nucleosides. All nucleosides were characterized with respect to their absorption and photochromic properties. Based on these results, the most promising photochromic DNA base modification was incorporated into representative oligonucleotides by using automated phosphoramidite chemistry. The switching of optical properties in DNA can be achieved selectively at 310 nm (forward) and 450 nm (backward); both wavelengths are outside the normal nucleic acid absorption range. Moreover, this nucleoside was proven to be photochemically stable and allows switching back and forth several times. These results open the way for the use of diarylethenes as photochromic compounds in DNA-based architectures.
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影响因子：
4.9
作者：
Hammarson, Martin;Andersson, Johanna;Andreasson, Joakim
通讯作者：
Andreasson, Joakim
影响因子：
3.2
作者：
Liang, Xingguo;Nishioka, Hidenori;Asanuma, Hiroyuki
通讯作者：
Asanuma, Hiroyuki
影响因子：
4.9
作者：
Nishioka, Hidenori;Liang, Xingguo;Asanuma, Hiroyuki
通讯作者：
Asanuma, Hiroyuki
影响因子：
4.3
作者：
Nishioka, Hidenori;Liang, Xingguo;Asanuma, Hiroyuki
通讯作者：
Asanuma, Hiroyuki
影响因子：
16.6
作者：
Nishioka, Hidenori;Liang, Xingguo;Asanuma, Hiroyuki
通讯作者：
Asanuma, Hiroyuki