Oxytocin Modulates Expression of Neuron and Glial Markers in the Rat Hippocampus.
Oxytocin Modulates Expression of Neuron and Glial Markers in the Rat Hippocampus.
复制标题
催产素调节大鼠海马神经元和神经胶质标记物的表达。
作者：
T. Havranek;Z. Lestanova;Boris Mravec;Vladimír Štrbák;J. Bakos;Z. Bacova
包括催产素在内的神经肽属于可能在控制神经元细胞存活、增殖和分化中起作用的一组因子。本研究的目的是通过测量大脑中特定神经元和神经胶质标记物的基因和蛋白质表达来研究催产素对神经元分化的潜在贡献。在Wistar大鼠中，新生儿和成人给予催产素以揭示催产素的发育和/或急性效应。21日龄和2月龄大鼠海马神经元特异性烯醇化酶（NSE）基因和蛋白表达增加。新生儿催产素处理诱导星形胶质细胞标志物-胶质原纤维酸蛋白（GFAP）基因和蛋白表达显著增加。催产素处理导致21日龄和2月龄大鼠少突胶质细胞标志物mRNA - 2′，3′-环核苷酸3′-磷酸二酯酶(CNPase) -减少，而小胶质细胞标志物CD68 mRNA未见变化。成年大鼠中枢后叶催产素可诱导NSE和CNPase基因表达显著增加。本研究提供了第一个揭示催产素对大脑神经元和神经胶质标记物表达影响的数据。这可能表明催产素系统参与调节大脑中神经元前体细胞的发育。
Neuropeptides including oxytocin belong to the group of factors that may play a role in the control of neuronal cell survival, proliferation and differentiation. The aim of the present study was to investigate potential contribution of oxytocin to neuronal differentiation by measuring gene and protein expression of specific neuron and glial markers in the brain. Neonatal and adult oxytocin administration was used to reveal developmental and/or acute effects of oxytocin in Wistar rats. Gene and protein expression of neuron-specific enolase (NSE) in the hippocampus was increased in 21-day and 2-month old rats in response to neonatal oxytocin administration. Neonatal oxytocin treatment induced a significant increase of gene and protein expression of the marker of astrocytes - glial fibrillary acid protein (GFAP). Oxytocin treatment resulted in a decrease of oligodendrocyte marker mRNA - 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) - in 21-day and 2-month old rats, while no change of CD68 mRNA, marker of microglia, was observed. Central oxytocin administration in adult rats induced a significant increase of gene expression of NSE and CNPase. The present study provides the first data revealing the effect of oxytocin on the expression of neuron and glial markers in the brain. It may be suggested that the oxytocin system is involved in the regulation of development of neuronal precursor cells in the brain.
成年人类海马神经发生的动力学。
影响因子：
64.5
作者：
Spalding KL;Bergmann O;Alkass K;Bernard S;Salehpour M;Huttner HB;Boström E;Westerlund I;Vial C;Buchholz BA;Possnert G;Mash DC;Druid H;Frisén J
通讯作者：
Frisén J
影响因子：
56.9
作者：
Bonni, A;Sun, Y;Greenberg, ME
通讯作者：
Greenberg, ME
星形胶质细胞的生长受神经肽通过 Tis 8 和碱性成纤维细胞生长因子的调节。
DOI：
10.1172/jci117167
发表时间：
1994
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Hu,RM;Levin,ER
通讯作者：
Levin,ER