Continuum modeling of the electric-field-induced tension in deforming lipid vesicles.

Continuum modeling of the electric-field-induced tension in deforming lipid vesicles.
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脂质囊泡变形过程中电场诱导张力的连续体建模。

DOI:
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发表时间:
2015
影响因子:
4.4
通讯作者:
Petia M. Vlahovska
Petia M. Vlahovska
中科院分区:
化学2区
文献类型:
--
作者:
L. C. McConnell;M. Miksis;Petia M. Vlahovska

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我们通过计算研究了封闭双层膜(囊泡)在直流电脉冲中的变形,目的是了解细胞电穿孔。施加在区域不可压缩界面上的电应力产生不均匀的张力,该张力可以超过膜溶解张力并驱动孔隙打开。使用二维边界积分方法,我们跟踪的最高膜张力的时空演变。我们的模拟突出了电张力的动态性质,与常见的假设相反,电穿孔远离两极的可能性。
We computationally investigate the deformation of a closed bilayer membrane (vesicle) in a DC electric pulse with a goal of understanding cell electroporation. The electric stresses exerted on the area-incompressible interface generate non-uniform tension that can exceed the membrane lysis tension and drive pore opening. Using the two-dimensional boundary integral method, we track the spatial and temporal evolution of the highest membrane tension. Our simulations highlight the dynamic nature of electrotension and, in contrast to the common assumption, a possibility of electroporation away from the poles.
DOI: 10.1016/s0006-3495(99)76973-0
发表时间: 1999-09-01
影响因子: 3.4
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DOI: 10.1103/physrevlett.87.208301
发表时间: 2001-11-12
影响因子: 8.6
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发表时间: 1989-05-01
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