Area 5 influences excitability within the primary motor cortex in humans.
Area 5 influences excitability within the primary motor cortex in humans.
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DOI：
10.1371/journal.pone.0020023
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Nelson A
中科院分区：
文献类型：
--
作者：
Premji A;Rai N;Nelson A
在非人类灵长类动物中，布罗德曼区 5 (BA 5) 与初级运动皮层 (M1) 直接相连，主要负责手部的表征，并且可能已经进化出执行熟练手部运动的能力。关于人类 BA 5 及其与手部控制相关的 M1 神经回路的相互作用，人们知之甚少。本研究探讨了 BA 5 对左半球 BA 5 进行连续 (cTBS)、间歇 (iTBS) 和假 θ 突发刺激 (假 TBS) 前后两侧 M1 内兴奋性和抑制性神经回路的影响。使用单脉冲和成对脉冲 TMS，测量运动诱发电位 (MEP)、短间隔皮质内抑制 (SICI) 和皮质内促进 (ICF)量化第一背侧骨间肌的表示。结果表明，BA 5 上的 cTBS 影响 M1 兴奋性，使得双侧 MEP 振幅增加长达一小时。 ITBS 超过 BA 5 会导致与刺激相反的 MEP 振幅增加，并延迟发作，可持续长达一小时。在TBS之后SICI和ICF在BA 5之后没有改变。同样，在cTBS之后在BA 5之后F波幅度和潜伏期没有改变。数据表明BA 5通过影响皮质脊髓神经元而不是介导SICI或ICF回路的中间神经元来改变指向手部的M1输出。通过 cTBS 和 iTBS 靶向 BA 5 是一种强有力地调节 M1 内活动的新机制，并可能为研究健康人群的手部控制和改变临床人群受损的手部功能提供途径。
In non-human primates, Brodmann's area 5 (BA 5) has direct connectivity with primary motor cortex (M1), is largely dedicated to the representation of the hand and may have evolved with the ability to perform skilled hand movement. Less is known about human BA 5 and its interaction with M1 neural circuits related to hand control. The present study examines the influence of BA 5 on excitatory and inhibitory neural circuitry within M1 bilaterally before and after continuous (cTBS), intermittent (iTBS), and sham theta-burst stimulation (sham TBS) over left hemisphere BA 5. Using single and paired-pulse TMS, measurements of motor evoked potentials (MEPs), short interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were quantified for the representation of the first dorsal interosseous muscle. Results indicate that cTBS over BA 5 influences M1 excitability such that MEP amplitudes are increased bilaterally for up to one hour. ITBS over BA 5 results in an increase in MEP amplitude contralateral to stimulation with a delayed onset that persists up to one hour. SICI and ICF were unaltered following TBS over BA 5. Similarly, F-wave amplitude and latency were unaltered following cTBS over BA 5. The data suggest that BA 5 alters M1 output directed to the hand by influencing corticospinal neurons and not interneurons that mediate SICI or ICF circuitry. Targeting BA 5 via cTBS and iTBS is a novel mechanism to powerfully modulate activity within M1 and may provide an avenue for investigating hand control in healthy populations and modifying impaired hand function in clinical populations.
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