The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis.

The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis.
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DOI:
10.3390/microorganisms6010022
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发表时间:
2018-03-09
期刊:
影响因子:
4.5
通讯作者:
Delhaes L
Delhaes L
中科院分区:
生物学3区
文献类型:
--
作者:
Enaud R;Vandenborght LE;Coron N;Bazin T;Prevel R;Schaeverbeke T;Berger P;Fayon M;Lamireau T;Delhaes L

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近年来,肠道微生物群被认为是肠-脑轴的成熟参与者,使得在理解神经和精神疾病的病理生理学方面迈出了新的一步。然而,大多数研究都专注于肠道细菌微生物群,而忘记了不可忽视的真菌菌群。在这篇综述中,我们通过真菌与宿主(特别是与免疫系统)和肠道细菌的相互作用,揭示了真菌成分在微生物群-肠-脑轴中的作用是如何合理的。我们还讨论了已发表的数据,这些数据已经证明了真菌组在微生物群-肠-脑轴中的作用,以及真菌对临床和治疗研究的影响。
In recent years, the gut microbiota has been considered as a full-fledged actor of the gut–brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterial microbiota, forgetting the non-negligible fungal flora. In this review, we expose how the role of the fungal component in the microbiota-gut-brain axis is legitimate, through its interactions with both the host, especially with the immune system, and the gut bacteria. We also discuss published data that already attest to a role of the mycobiome in the microbiota-gut-brain axis, and the impact of fungi on clinical and therapeutic research.
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