Protective Microbiota: From Localized to Long-Reaching Co-Immunity.
Protective Microbiota: From Localized to Long-Reaching Co-Immunity.
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DOI：
10.3389/fimmu.2017.01678
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发表时间：
2017
影响因子：
7.3
通讯作者：
Pradeu T
中科院分区：
文献类型：
--
作者：
Chiu L;Bazin T;Truchetet ME;Schaeverbeke T;Delhaes L;Pradeu T
常驻微生物群不仅塑造宿主免疫力，它们还有助于宿主抵御病原体和传染病。以前对微生物群的保护作用的综述只集中在微环境内的定殖抗性上。该综述表明，针对病原体的保护还涉及在不消除病原体的情况下减轻病原体的影响（即，“疾病耐受性”）和遏制微生物以防止病原体传播。保护性微生物可以产生超出其生态位的影响，干扰病原微生物的进入，建立，生长和传播。更根本的是，我们提出了一系列概念上的澄清，以支持“共同免疫”的想法，其中一个生物体受到自身免疫系统和其微生物群成分的保护。
Resident microbiota do not just shape host immunity, they can also contribute to host protection against pathogens and infectious diseases. Previous reviews of the protective roles of the microbiota have focused exclusively on colonization resistance localized within a microenvironment. This review shows that the protection against pathogens also involves the mitigation of pathogenic impact without eliminating the pathogens (i.e., “disease tolerance”) and the containment of microorganisms to prevent pathogenic spread. Protective microorganisms can have an impact beyond their niche, interfering with the entry, establishment, growth, and spread of pathogenic microorganisms. More fundamentally, we propose a series of conceptual clarifications in support of the idea of a “co-immunity,” where an organism is protected by both its own immune system and components of its microbiota.
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影响因子：
30.3
作者：
Benson A;Pifer R;Behrendt CL;Hooper LV;Yarovinsky F
通讯作者：
Yarovinsky F
影响因子：
64.5
作者：
Ayres JS
通讯作者：
Ayres JS
DOI：
10.1073/pnas.1305923110
发表时间：
2013-06-25
影响因子：
11.1
作者：
Barr, Jeremy J.;Auro, Rita;Rohwer, Forest
通讯作者：
Rohwer, Forest
影响因子：
2.8
作者：
Botes, Marelize;Loos, Ben;Dicks, Leon M. T.
通讯作者：
Dicks, Leon M. T.
影响因子：
--
作者：
ASHBURNER, F;MUSHIN, R
通讯作者：
MUSHIN, R