The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review.
The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review.
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DOI：
10.3390/ijms23116075
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发表时间：
2022-05-28
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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自噬是通过溶酶体依赖性机制降解多余或受损细胞物质的进化保守过程，有助于细胞稳态和存活。自噬在癌症的发生、维持和进展中起着多方面和依赖于环境的作用;它在没有疾病的情况下具有肿瘤抑制作用，并在癌细胞中上调以满足其升高的代谢需求。自噬是癌症治疗中一个有前途但具有挑战性的靶点。绿色茶是一种广泛使用的饮料，对包括癌症在内的多种疾病具有健康作用。绿色茶的生物活性物质主要是儿茶素类，其中表没食子儿茶素没食子酸酯（EGCG）含量最丰富，生物活性最强。在这篇综述中，自噬调节和抗癌作用的证据诱导的表没食子儿茶素没食子酸酯治疗在实验性癌症模型。综述的文献显示，EGCG通常通过使PI 3 K/Akt/mTOR通路失活而促进细胞毒性自噬，导致细胞凋亡诱导。EGCG的促氧化活性被认为是其抗癌作用的原因。在与化疗药物的联合治疗中，EGCG抑制细胞生长和药物诱导的促生存自噬。所选的研究正确地声称表没食子儿茶素没食子酸酯是一种有价值的癌症化学预防剂。
Autophagy is an evolutionarily conserved process for the degradation of redundant or damaged cellular material by means of a lysosome-dependent mechanism, contributing to cell homeostasis and survival. Autophagy plays a multifaceted and context-dependent role in cancer initiation, maintenance, and progression; it has a tumor suppressive role in the absence of disease and is upregulated in cancer cells to meet their elevated metabolic demands. Autophagy represents a promising but challenging target in cancer treatment. Green tea is a widely used beverage with healthy effects on several diseases, including cancer. The bioactive compounds of green tea are mainly catechins, and epigallocatechin-gallate (EGCG) is the most abundant and biologically active among them. In this review, evidence of autophagy modulation and anti-cancer effects induced by EGCG treatment in experimental cancer models is presented. Reviewed articles reveal that EGCG promotes cytotoxic autophagy often through the inactivation of PI3K/Akt/mTOR pathway, resulting in apoptosis induction. EGCG pro-oxidant activity has been postulated to be responsible for its anti-cancer effects. In combination therapy with a chemotherapy drug, EGCG inhibits cell growth and the drug-induced pro-survival autophagy. The selected studies rightly claim EGCG as a valuable agent in cancer chemoprevention.
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作者：
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