Neural lineage tracing in the mammalian brain.

Neural lineage tracing in the mammalian brain.
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DOI:
10.1016/j.conb.2017.10.013
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发表时间:
2018-06
影响因子:
5.7
通讯作者:
Shi SH
Shi SH
中科院分区:
医学2区
文献类型:
--
作者:
Ma J;Shen Z;Yu YC;Shi SH

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Delineating the lineage of neural cells that captures the progressive steps in their specification is fundamental to understanding brain development, organization, and function. Since the earliest days of embryology, lineage questions have been addressed with methods of increasing specificity, capacity, and resolution. Yet, a full realization of individual cell lineages remains challenging for complex systems. A recent explosion of technical advances in genome-editing and single-cell sequencing has enabled lineage analysis in an unprecedented scale, speed, and depth across different species. In this review, we discuss the application of available as well as future genetic labeling techniques for tracking neural lineages in vivo in the mammalian nervous system.
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