Clonal production and organization of inhibitory interneurons in the neocortex.
Clonal production and organization of inhibitory interneurons in the neocortex.
复制标题
新皮层中抑制性神经元的克隆生产和组织。
DOI：
10.1126/science.1208884
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发表时间：
2011-10-28
期刊：
影响因子：
--
通讯作者：
Shi SH
中科院分区：
文献类型：
--
作者：
Brown KN;Chen S;Han Z;Lu CH;Tan X;Zhang XJ;Ding L;Lopez-Cruz A;Saur D;Anderson SA;Huang K;Shi SH
新皮层包含兴奋性神经元和抑制性中间神经元。源自同一祖细胞的新皮层兴奋性神经元的克隆在空间上是有组织的，并有助于功能性微电路的形成。相比之下，对新皮层抑制性中间神经元的产生和组织知之甚少。我们发现，新皮层抑制性中间神经元产生的空间组织克隆单位在发展腹侧端脑。此外，克隆相关的中间神经元没有随机分散，但在新皮层形成空间孤立的集群。单个克隆集群组成的interneurons表达相同或不同的神经化学标记物表现出明确的垂直或水平组织。这些结果表明，谱系关系在新皮层抑制性中间神经元的组织中起着关键作用。
The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical excitatory neurons originating from the same progenitor cell are spatially organized and contribute to the formation of functional microcircuits. In contrast, relatively little is known about the production and organization of neocortical inhibitory interneurons. We found that neocortical inhibitory interneurons were produced as spatially organized clonal units in the developing ventral telencephalon. Furthermore, clonally related interneurons did not randomly disperse but formed spatially isolated clusters in the neocortex. Individual clonal clusters consisting of interneurons expressing the same or distinct neurochemical markers exhibited clear vertical or horizontal organization. These results suggest that the lineage relationship plays a pivotal role in the organization of inhibitory interneurons in the neocortex.
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