Prostate Microbiota and Prostate Cancer: A New Trend in Treatment.
Prostate Microbiota and Prostate Cancer: A New Trend in Treatment.
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DOI：
10.3389/fonc.2021.805459
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发表时间：
2021
影响因子：
4.7
通讯作者：
Tang K
中科院分区：
文献类型：
--
作者：
Che B;Zhang W;Xu S;Yin J;He J;Huang T;Li W;Yu Y;Tang K
尽管前列腺癌的发病率和死亡率在过去几年里逐渐开始下降，但它仍然是世界上恶性肿瘤死亡的主要原因之一。前列腺癌的发生发展受种族、家族史、微环境等因素的影响。近几十年来，越来越多的研究证实，肿瘤微环境中的前列腺菌群在前列腺癌的发生、发展和预后中可能起着重要作用。微生物或其代谢产物可能影响癌细胞的发生和转移，或调节抗癌免疫监视。此外，肿瘤微环境细菌在肿瘤介入靶向治疗中的应用也显示出独特的优势。本文介绍了微生物区系在前列腺癌中的作用途径，重点介绍了微生物在肿瘤发生发展中的作用机制，以及微生物作为肿瘤生物标志物和肿瘤防治的前景和意义。
Although the incidence and mortality of prostate cancer have gradually begun to decline in the past few years, it is still one of the leading causes of death from malignant tumors in the world. The occurrence and development of prostate cancer are affected by race, family history, microenvironment, and other factors. In recent decades, more and more studies have confirmed that prostate microflora in the tumor microenvironment may play an important role in the occurrence, development, and prognosis of prostate cancer. Microorganisms or their metabolites may affect the occurrence and metastasis of cancer cells or regulate anti-cancer immune surveillance. In addition, the use of tumor microenvironment bacteria in interventional targeting therapy of tumors also shows a unique advantage. In this review, we introduce the pathway of microbiota into prostate cancer, focusing on the mechanism of microorganisms in tumorigenesis and development, as well as the prospect and significance of microorganisms as tumor biomarkers and tumor prevention and treatment.
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