Association of lifetime cognitive engagement and low β-amyloid deposition.
Association of lifetime cognitive engagement and low β-amyloid deposition.
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DOI：
10.1001/archneurol.2011.2748
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发表时间：
2012-05
影响因子：
--
通讯作者：
Jagust, William J.
中科院分区：
文献类型：
--
作者：
Landau, Susan M.;Marks, Shawn M.;Mormino, Elizabeth C.;Rabinovici, Gil D.;Oh, Hwamee;O'Neil, James P.;Wilson, Robert S.;Jagust, William J.
评估健康老年人生活方式（认知和体力活动）与β-淀粉样蛋白沉积之间的相关性，使用碳11标记的匹兹堡化合物B（[11 C] Pi B）通过正电子发射断层扫描进行测量。横断面临床研究。伯克利，加州。从2005年10月31日至2011年2月22日，对65名健康老年人（平均年龄76.1岁）、10名阿尔茨海默病（AD）患者（平均年龄74.8岁）和11名年轻对照（平均年龄24.5岁）的志愿者样本进行了研究。皮质[11 C]PiB平均值（额叶、顶叶、侧颞和扣带区域）和回顾性自我报告量表，评估认知活动（例如，阅读、写作和玩游戏）和体育锻炼的参与情况。一生中更多地参与认知刺激活动，特别是在早期和中年，与[11 C]PiB摄取减少有关（P <0.001，考虑年龄，性别和受教育年限）。认知活动最高三分位数的老年参与者的[11 C]PiB摄取与年轻对照组相当，而认知活动最低三分位数的老年参与者的[11 C]PiB摄取与AD患者相当。虽然更多的认知活动与更多的体育锻炼有关，但运动与[11 C]PiB摄取无关。早期和中年认知活动更强的个体[11 C]PiB摄取量较低。参与认知刺激活动的倾向可能与参与各种生活方式实践有关，这些生活方式实践在其他研究中表明AD相关病理学风险降低。我们报告了认知活动与[11 C]PiB摄取之间的直接关联，表明在具有高认知参与的个体中发现的生活方式因素可能会阻止或减缓β-淀粉样蛋白的沉积，可能影响AD的发作和进展。
To assess the association between lifestyle practices (cognitive and physical activity) and β-amyloid deposition, measured with positron emission tomography using carbon 11–labeled Pittsburgh Compound B ([11C]PiB), in healthy older individuals. Cross-sectional clinical study. Berkeley, California. Volunteer sample of 65 healthy older individuals (mean age, 76.1 years), 10 patients with Alzheimer disease (AD) (mean age, 74.8 years), and 11 young controls (mean age, 24.5 years) were studied from October 31, 2005, to February 22, 2011. Cortical [11C]PiB average (frontal, parietal, lateral temporal, and cingulate regions) and retrospective, self-report scales assessing participation in cognitive activities (eg, reading, writing, and playing games) and physical exercise. Greater participation in cognitively stimulating activities across the lifespan, but particularly in early and middle life, was associated with reduced [11C]PiB uptake (P <.001, accounting for age, sex, and years of education). Older participants in the highest cognitive activity tertile had [11C]PiB uptake comparable to young controls, whereas those in the lowest cognitive activity tertile had [11C]PiB uptake comparable to patients with AD. Although greater cognitive activity was associated with greater physical exercise, exercise was not associated with [11C]PiB uptake. Individuals with greater early- and middle-life cognitive activity had lower [11C]PiB uptake. The tendency to participate in cognitively stimulating activities is likely related to engagement in a variety of lifestyle practices that have been implicated in other studies showing reduced risk of AD-related pathology. We report a direct association between cognitive activity and [11C]PiB uptake, suggesting that lifestyle factors found in individuals with high cognitive engagement may prevent or slow deposition of β-amyloid, perhaps influencing the onset and progression of AD.
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DOI：
10.1126/science.1180962
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kang JE;Lim MM;Bateman RJ;Lee JJ;Smyth LP;Cirrito JR;Fujiki N;Nishino S;Holtzman DM
通讯作者：
Holtzman DM
淀粉样蛋白β动力学与受伤的人脑中的神经系统状况相关。
影响因子：
56.9
作者：
Brody, David L.;Magnoni, Sandra;Schwetye, Kate E.;Spinner, Michael L.;Esparza, Thomas J.;Stocchetti, Nino;Zipfel, Gregory J.;Holtzman, David M.
通讯作者：
Holtzman, David M.
影响因子：
16.2
作者：
Kamenetz, F;Tomita, T;Malinow, R
通讯作者：
Malinow, R
影响因子：
14.5
作者：
Pike, Kerryn E.;Savage, Greg;Rowe, Christopher C.
通讯作者：
Rowe, Christopher C.
影响因子：
19.9
作者：
Jagust, William J.;Mormino, Elizabeth C.
通讯作者：
Mormino, Elizabeth C.