Hesitancy for receiving regular SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis from the UK-REACH study.
Hesitancy for receiving regular SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis from the UK-REACH study.
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犹豫不决在英国医疗保健工作者中进行定期的SARS-COV-2疫苗接种：英国范围研究的横断面分析。
DOI：
10.1186/s12916-022-02588-7
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发表时间：
2022-10-10
期刊：
影响因子：
9.3
通讯作者：
Pareek, Manish
中科院分区：
文献类型：
--
作者：
Veli, Neyme;Martin, Christopher A.;Woolf, Katherine;Nazareth, Joshua;Pan, Daniel;Al-Oraibi, Amani;Baggaley, Rebecca F.;Bryant, Luke;Nellums, Laura B.;Gray, Laura J.;Khunti, Kamlesh;Pareek, Manish
可能需要定期接种SARS-CoV-2疫苗，以保持“高危”人群的免疫力，其中包括医护人员(HCW)。然而，对于可能对接受假设的常规SARS-CoV-2疫苗接种犹豫不决的卫生工作者比例或与这种犹豫不决相关的因素，我们知之甚少。对收集的问卷数据进行横断面分析，作为UK-REACH的一部分，这是一项全国性的、对卫生工作者的纵向队列研究。结果的衡量标准是二元的，要么参与者表示如果推荐他们肯定会接受常规的SARS-CoV-2疫苗接种，要么他们对接受与否表示某种程度的犹豫(可能接受或不太可能接受)。我们使用Logistic回归来确定与定期接种疫苗犹豫不决相关的因素。共有5454名医务工作者被纳入分析队列，其中23.5%的人对是否定期接种SARS-CoV-2疫苗持犹豫态度。黑人妇女比白人妇女更有可能犹豫不决(AOR 2.60，95%CI 1.80-3.72)，那些报告过先前新冠肺炎发作的人也是如此(1.33，1.13-1.57[与检测阴性的人相比])。在前两个季节接种过流感疫苗的人对定期接种SARS-CoV-2疫苗感到犹豫的可能性比在这两个季节都没有接种过流感疫苗的人低五倍以上(0.18，0.14-0.21)。信任官方疫苗信息来源(如NHS或政府广告或网站)的卫生工作者不太可能报告对常规疫苗接种计划的犹豫不决。那些从朋友和家人那里接触到反对接种疫苗的信息的人更有可能犹豫。在这项研究中，近四分之一的英国医务工作者对是否接受常规的SARS-CoV-2疫苗接种犹豫不决。我们已经确定了与常规接种SARS-CoV-2疫苗犹豫不决相关的关键因素，这可以用来识别疫苗迟疑风险最高的卫生工作者群体，并相应地定制干预措施。卫生工作者的家人和朋友可能会影响定期接种疫苗的决定。这意味着，与卫生工作者及其社交网络合作，缓解人们对SARS-CoV-2疫苗接种的担忧，可以提高常规疫苗接种计划的接种率。ISRCTN注册表，ISRCTN11811602。网上版载有补充材料，可在10.1186/s12916-022-02588-7查阅。
Regular vaccination against SARS-CoV-2 may be needed to maintain immunity in ‘at-risk’ populations, which include healthcare workers (HCWs). However, little is known about the proportion of HCWs who might be hesitant about receiving a hypothetical regular SARS-CoV-2 vaccination or the factors associated with this hesitancy. Cross-sectional analysis of questionnaire data collected as part of UK-REACH, a nationwide, longitudinal cohort study of HCWs. The outcome measure was binary, either a participant indicated they would definitely accept regular SARS-CoV-2 vaccination if recommended or they indicated some degree of hesitancy regarding acceptance (probably accept or less likely). We used logistic regression to identify factors associated with hesitancy for receiving regular vaccination. A total of 5454 HCWs were included in the analysed cohort, 23.5% of whom were hesitant about regular SARS-CoV-2 vaccination. Black HCWs were more likely to be hesitant than White HCWs (aOR 2.60, 95%CI 1.80–3.72) as were those who reported a previous episode of COVID-19 (1.33, 1.13–1.57 [vs those who tested negative]). Those who received influenza vaccination in the previous two seasons were over five times less likely to report hesitancy for regular SARS-CoV-2 vaccination than those not vaccinated against influenza in either season (0.18, 0.14–0.21). HCWs who trusted official sources of vaccine information (such as NHS or government adverts or websites) were less likely to report hesitancy for a regular vaccination programme. Those who had been exposed to information advocating against vaccination from friends and family were more likely to be hesitant. In this study, nearly a quarter of UK HCWs were hesitant about receiving a regular SARS-CoV-2 vaccination. We have identified key factors associated with hesitancy for regular SARS-CoV-2 vaccination, which can be used to identify groups of HCWs at the highest risk of vaccine hesitancy and tailor interventions accordingly. Family and friends of HCWs may influence decisions about regular vaccination. This implies that working with HCWs and their social networks to allay concerns about SARS-CoV-2 vaccination could improve uptake in a regular vaccination programme. ISRCTN Registry, ISRCTN11811602. The online version contains supplementary material available at 10.1186/s12916-022-02588-7.
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影响因子：
7.8
作者：
Garcia, Lauren;Firek, Anthony;Freund, Deborah;Massai, Donatella;Khurana, Dhruv;Lee, Jerusha E.;Zamarripa, Susanna;Sasaninia, Bijan;Michaels, Kelsey;Nightingale, Judi;Gatto, Nicole M.
通讯作者：
Gatto, Nicole M.
BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
16.6
作者：
Nguyen LH;Joshi AD;Drew DA;Merino J;Ma W;Lo CH;Kwon S;Wang K;Graham MS;Polidori L;Menni C;Sudre CH;Anyane-Yeboa A;Astley CM;Warner ET;Hu CY;Selvachandran S;Davies R;Nash D;Franks PW;Wolf J;Ourselin S;Steves CJ;Spector TD;Chan AT;COPE Consortium
通讯作者：
COPE Consortium
影响因子：
5.4
作者：
Rhead RD;Chui Z;Bakolis I;Gazard B;Harwood H;MacCrimmon S;Woodhead C;Hatch SL
通讯作者：
Hatch SL
影响因子：
7.8
作者：
Pal S;Shekhar R;Kottewar S;Upadhyay S;Singh M;Pathak D;Kapuria D;Barrett E;Sheikh AB
通讯作者：
Sheikh AB